| 组织芯片技术研究P16INK4A和Ki67在宫颈鳞状上皮病变中的表达 |
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| 引用本文： | 农林琳,陈秋月,林静,乐江华,侯巧燕.组织芯片技术研究P16INK4A和Ki67在宫颈鳞状上皮病变中的表达[J].现代医药卫生,2011,27(21):3207-3208. |
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| 作者姓名： | 农林琳 陈秋月 林静 乐江华 侯巧燕 |
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| 作者单位： | 1. 桂林医学院,广西桂林,541004
2. 桂林医学院附属医院,广西桂林,541001 |
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| 基金项目： | 2008年广西卫生厅自筹科研课题(编号:Z2008279); 2009年桂林医学院基础医学院科研课题(编号:JCKY200903) |
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| 摘 要： | 目的:利用组织芯片技术及免疫组化技术检测在正常宫颈组织、宫颈上皮内瘤变及宫颈鳞状细胞癌中P16INK4A和Ki67的表达情况及其意义.方法:应用免疫组化技术检测53例宫颈组织(正常宫颈9例,宫颈上皮内瘤变32例,宫颈鳞状细胞癌12例)制成的组织芯片中P 16INK4A和Ki67的表达,并比较3组的表达情况及其相互关系.结果:P16INK4A和Ki67在正常组中阳性率分别为0.00％ (0/9)和11.11％(1/9)；CIN组中阳性率分别为78.13％(25/32)和68.75％ (22/32)；鳞状细胞癌组中阳性率均为91.67％(11/12).其中正常组与CIN组、正常组与癌组、正常组与CIN组和癌组比较差异极有统计学意义(P＜0.01).此外,P16INK4A和Ki67的表达密切相关(P＜0.05).结论:P16INK4A和Ki67表达与宫颈鳞状上皮病变的发生发展密切相关,两者表达相关性提示可能共同参与肿瘤的发生发展.
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| 关 键 词： | P16INK4A Ki67 宫颈鳞状上皮病变 组织芯片 |
Expressions of P16INK4A and Ki67 in cervical squamous intraepithelial lesions by tissue microarray |
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| NONG Lin-lin
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CHEN Qiu-yue
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LIN Jing
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LE Jiang-hua
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HOU Qiao-yan.Expressions of P16INK4A and Ki67 in cervical squamous intraepithelial lesions by tissue microarray[J].Modern Medicine Health,2011,27(21):3207-3208. |
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| Authors: | NONG Lin-lin CHEN Qiu-yue LIN Jing LE Jiang-hua HOU Qiao-yan |
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| Institution: | 1.Guilin Medical University,Guilin,Guangxi 541004,China;2.Affiliated Hospital,Guilin Medical University,Guilin,Guangxi 541001,China) |
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| Abstract: | Objective:To investigate the expressions and significance of P16INK4A and Ki67 in normal cervical tissue,cervical intraepithelial neoplasia(CIN) and cervical squamous cell carcinoma by tissue microarray technology and immunohitochemistry techenique.Methods:The immunohitochemistry technique was adopted to detect the expressions of P16INK4A and Ki67 of tissue microarray in 53 cases of cervical tissue(9 cases of normal cervix,32 cases of CIN and 12 cases of cervical squamous cell carcinoma).The expressions in ... |
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| Keywords: | P16INK4A Ki67 Cervical squamous intraepithelial lesions Tissue microarray |
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