妊高征患者母血及胎盘组织中卵泡休止素水平变化的研究

目的 :研究妊高征患者母血及胎盘组织中卵泡休止素 (FS)水平变化的临床意义。方法 :采用固相双夹心酶联免疫吸附 (ELISA)法测定妊高征组 (轻度 4例、中度 4例、重度 12例 )及正常妊娠组 (34例 )孕妇血清以及胎盘组织 (两组各 10例 )FS含量。结果 :妊高征组血清FS水平低于正常妊娠组 (P <0 .0 0 1) ;重度妊高征组血清FS水平低于轻中度妊高征组 (P<0 .0 5 ) ;妊高征组胎盘组织FS含量低于正常妊娠组 (P<0 .0 0 1) ;两组血清FS水平与胎盘组织FS含量呈显著的直线相关关系 (P <0 .0 5 )。结论 :FS下降可能参与妊高征的发生、发展。血清FS值可与其它指标相结合用于胎盘功能的评价

Changes of Follistatin in Maternal Serum and Placenta in Pregnancy-Induced Hypertension Syndrome

Objective: Our aim was to study changes of levels of follistatin (FS) in maternal serum and placenta in pregnancy induced hypertension syndrome(PIH) and the clinical significance. Methods: Level of FS was measured by using ELISA in 20 patients with PIH and 34 women in normal pregnancy. Results: Level of FS in maternal serum in PIH group was significantly reduced compared with that in normal pregnancy group (P<0.001); and was lower in severe PIH group than that in mild to moderate PIH group (P<0.01); Level of FS in placenta was lower in PIH group than that in normal pregnancy group (P<0.01). In both PIH group and normal pregnancy group, level of FS in maternal serum was related with that of placenta (P<0.05). Conclusion: Follistatin may involve in the progression of PIH. Level of FS in maternal serum can be used as an index for the assessment of placenta function.