| 原子力显微镜碳纳米管探针的制备及其生物学应用 |
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| 引用本文： | 赵铁强,国立秋,董申,张飞虎.原子力显微镜碳纳米管探针的制备及其生物学应用[J].生物医学工程学杂志,2003,20(2):352-355. |
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| 作者姓名： | 赵铁强 国立秋 董申 张飞虎 |
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| 作者单位： | 1. 哈尔滨工业大学精密工程研究所,哈尔滨,150001;哈尔滨医科大学第一临床医学院心内科,哈尔滨,150001
2. 哈尔滨工业大学精密工程研究所,哈尔滨,150001 |
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| 基金项目： | 国家自然科学基金资助项目 (5 0 2 0 5 0 0 6)，哈尔滨工业大学跨学科交叉性研究基金资助项目 (HIT. MD.2 0 0 1.0 4) |
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| 摘 要： | 原子力显微镜(Atomic force microscope，AFM)具有原子级分辨率，探针是决定其分辨率的核心部件。碳纳米管以其独特的结构和理化性质，成为理想的AFM探针。碳纳米管探针可用手工法和化学气相沉积法制备。在多种蛋白质、核酸、细胞的研究中，碳纳米管探针不仅能获得高分辨率的图像，还有助于判断特定的DNA序列及确定单元型，必将在生物学领域起到越来越重要的作用。
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| 关 键 词： | 原子力显微镜 碳纳米管探针 制备 生物结构 DNA序列 |
Preparation and Biological Application of Carbon Nanotube Atomic Force Microscope Probe |
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| Tieqiang Zhao,Liqiu Guo,Shen Dong,Feihu Zhang.Preparation and Biological Application of Carbon Nanotube Atomic Force Microscope Probe[J].Journal of Biomedical Engineering,2003,20(2):352-355. |
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| Authors: | Tieqiang Zhao Liqiu Guo Shen Dong Feihu Zhang |
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| Institution: | Precision Engineering Research Institute, Harbin Institute of Technology, Department of Cardiology, First Clinical College of Harbin Medical University, Harbin 150001. tqzhao@sohu.com |
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| Abstract: | The atomic force microscope(AFM) with an atomic resolution is a powerful tool for biological structure. The probe is an important part that determines the resolution of AFM. Carbon nanotube is becoming an ideal AFM probe due to its unique structure physical and chemical properties. Carbon nanotube AFM probes can be made by manual assembly or chemical vapor deposition. Several proteins, nucleic acids and cells have been investigated with carbon nanotube probes. Not only the high resolution images but also the determination of specific DNA sequence and haplotype were acquired. Carbon nanotube AFM probe will increasingly play an important role in biological studies. |
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| Keywords: | Atomic force microscopy Carbon nanotube Probe Biology |
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