Serum β2-microglobulin levels in psoriatic patients |
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| Authors: | Ayla Gü lekon,Nahide Gö kcora,M. Ali Gü rer,Vahide Baysal,Pervin Sezgin,Nilsel Keskin |
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| Affiliation: | Departments of Dermatology, School of Medicine, Gazi University, Ankara, Turkey;Departments of Nuclear Medicine, School of Medicine, Gazi University, Ankara, Turkey |
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| Abstract: | β2-Microglobulin (β2-M) is a low molecular weight protein forming the light chain of the class I major histocompatibility complex. It is found on the cell surface of all nucleated cells. Its serum concentration is found to be increased in kidney diseases, neoplasia, AIDS, chronic inflammation and autoimmune diseases. Inflammation plays an important role in the pathogenesis of psoriasis, especially psoriatic arthritis and immunological upset is one of the most implicated factors in the etiology of the disease. In this study, the sera β2-M levels were evaluated in cases diagnosed as psoriasis vulgaris and psoriatic arthritis, and a statistically significant increase was found in cases of psoriatic arthritis compared to those of psoriasis vulgaris and the control group. |
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| Keywords: | Psoriasis vulgaris Psoriatic arthritis β2-Microglobulin |
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