| 平卧菊三七叶化学成分的分离与鉴定 |
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| 引用本文： | 张 颖,姜 坤,杨利军,谭俊杰,孟大利,谭昌恒. 平卧菊三七叶化学成分的分离与鉴定[J]. 沈阳药科大学学报, 2012, 29(5): 337-339 |
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| 作者姓名： | 张 颖 姜 坤 杨利军 谭俊杰 孟大利 谭昌恒 |
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| 作者单位： | 1. 沈阳药科大学 基于靶点的药物设计与研究教育部重点实验室,辽宁 沈阳 110016;2. 中国科学院上海药物研究所 天然药物化学研究室, 上海 201203 |
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| 基金项目： | 国家“重大新药创制”科技重大专项资助项目(2009ZX09301-001) |
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| 摘 要： | 目的研究平卧菊三七叶子的化学成分。方法采用硅胶柱色谱法、反相ODS柱色谱法、Seph-adex LH-20柱色谱法和HPLC法等进行分离纯化,并通过波谱分析技术鉴定其化学结构。结果从平卧菊三七叶子中分离得到7个化合物,分别鉴定为β-谷甾醇-3-O-龙胆二糖苷(β-sitosterol-3-O-gentiobioside,1)、3-吲哚甲酸(indole-3-carboxylic acid,2)、蚱蜢酮(grasshopper ketone,3)、β-谷甾醇(β-sitosterol,4)、毒豆甲酮(drummondone A,5)、正三十二烷醇(n-dotriacontanol,6)和毒豆乙酮(drummondone B,7)。结论化合物1～3、5、7为首次从菊三七属植物中分离得到,化合物4、6为首次从平卧菊三七中分离得到。
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| 关 键 词： | 平卧菊三七 化学成分 结构鉴定 |
| 收稿时间： | 2011-12-19 |
| 修稿时间： | 2012-02-19 |
Isolation and identification of chemical constituents from leaves of Gynura procumbens (Lour.) Merr. |
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| ZHANG Ying,JIANG Kun,YANG Li-jun,TAN Jun-jie,MENG Da-li,TAN Chang-heng. Isolation and identification of chemical constituents from leaves of Gynura procumbens (Lour.) Merr.[J]. Journal of Shenyang Pharmaceutical University, 2012, 29(5): 337-339 |
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| Authors: | ZHANG Ying JIANG Kun YANG Li-jun TAN Jun-jie MENG Da-li TAN Chang-heng |
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| Affiliation: | 1.Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education,Shenyang Pharmaceutical University,Shenyang 110016,China;2.Department of Natural Medicinal Chemistry,Shanghai Institute of Materia Medica,CAS,Shanghai 201203,China) |
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| Abstract: | Objective To study the chemical constituents of leaves of Gynura procumbens(Lour.)Merr.Methods The compounds were isolated by chromatography on silica gel colunm,C18 reversed-phase column,Sephadex LH-20 column and HPLC,and their structures were determined on the basis of spectral analysis.Results Seven compounds were obtained and identified as β-sitosterol-3-O-gentiobioside(1),indole-3-carboxylic acid(2),grasshopper ketone(3),β-sitosterol(4),drummondone A(5),n-dotriacontanol(6),drummondone B(7).Conclusions Compounds 1-3,5 and 7 are isolated from Gynura genus firstly,while compounds 4 and 6 are isolated from Gynura procumbens(Lour.)Merr.for the first time. |
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| Keywords: | Gynura procumbens (Lour.) Merr.')" >Gynura procumbens (Lour.) Merr. chemical constituent ')" >structure identification |
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