| 盐酸头孢他美酯健康人体药动学研究 |
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| 引用本文： | 刘皋林,缪海均,邓渝林,樊成辉,陶霞.盐酸头孢他美酯健康人体药动学研究[J].中国药学杂志,2004,39(1):54-56. |
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| 作者姓名： | 刘皋林 缪海均 邓渝林 樊成辉 陶霞 |
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| 作者单位： | 第二军医大学长征医院药学部,上海,200003 |
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| 摘 要： | 目的 研究头孢他美酯在健康人体内的药动学。方法 18名健康志愿者单剂量po盐酸头孢他美酯片500mg ,采用高效液相色谱法测定血浆和尿中活性代谢物头孢他美药物浓度。结果 药动学参数末端相消除半衰期(t1/2)、峰浓度(cmax)、AUC0～12分别为:(2.52±0.47)h,(3.67±0.98)μg·mL-1,(21.10±5.19)μg·h·mL-1。结论 头孢他美的体内过程符合二室开放模型,主要经肾脏排出体外,12h累积尿排百分率为(36.00±8.62)%。
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| 关 键 词： | 头孢他美酯 头孢他美 高效液相色谱法 药动学 |
| 文章编号： | 1001-2494(2004)01-0054-03 |
| 收稿时间： | 2003-03-24; |
Study on pharmacokinetics of cefetamet pivoxil in healthy volunteers |
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| LIU Gao lin,MIAO Hai jun,DENG Yu lin,FAN Cheng hui,TAO Xia.Study on pharmacokinetics of cefetamet pivoxil in healthy volunteers[J].Chinese Pharmaceutical Journal,2004,39(1):54-56. |
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| Authors: | LIU Gao lin MIAO Hai jun DENG Yu lin FAN Cheng hui TAO Xia |
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| Institution: | Department ofPharmacy,ChangzhengHospital,Second Military Medical University,Shanghai200003,China |
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| Abstract: | OBJECTIVE To study the pharmacokinetics of cefetamet pivoxil in 18 healthy volunteers after oral administration of 500 mg cefetamet pivoxil hydrochloride tablet.METHOD The concentrations of cefetamet in plasma and urine were measured by an improved HPLC method.RESULTS The results showed that the terminal phase plasma elimination half life (t1/2),peak plasma level (cmax),area under plasma concentration time curve(AUC) were (2.52±0.47) h,(3.67±0.98)μg·mL-1,(21.1±5.19)μg·h·mL-1,respectively.CONCLUSION The plasma concentration time curve of cefetamet conformed to a two compartment open pharmacokinetic model.Cefetamet is mainly excreted through kidney in unchanged form.The cumulative urinary excretive rate of cefetamet was (36.0±8.62)% within 12 h after administration. |
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| Keywords: | cefetamet pivoxil cefetamet HPLC pharmacokinetics |
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