草木犀流浸液片治疗慢性鼻窦炎的疗效观察

目的:临床观察草木犀流浸液片对慢性鼻窦炎的疗效,探索治疗慢性鼻窦炎疗效好而不良反应少的药物。方法:选取耳鼻咽喉科门诊诊断为慢性鼻窦炎患者120例,随机分成观察组和对照组,每组60例,观察组采用草木犀流浸液片口服,3片/次,3次/d,连续治疗6周;对照组用低剂量克拉霉素250 mg,1次/d,连续治疗6周;观察并记录两组患者治疗前后的视觉模拟分级评分(VAS)及Lund-Mackey鼻窦CT评分,同时记录患者出现的药物不良反应。结果:观察组治疗前视觉模拟分级评分平均为(7.96±1.85)分,Lund-Mackey鼻窦CT评分平均为(7.16±1.51)分,治疗6周后视觉模拟分级评分平均为(3.28±1.05)分,Lund-Mackey鼻窦CT评分平均为(3.07±1.15)分;对照组治疗前视觉模拟分级评分平均为(8.04±1.79)分,Lund-Mackey鼻窦CT评分平均为(7.08±1.47)分,治疗6周后视觉模拟分级评分平均为(3.41±1.13)分,Lund-Mackey鼻窦CT评分平均为(3.18±1.09)分;观察组和对照组治疗前后组内相比较差异有统计学意义(P<0.05),但两组间相比较,差异无统计学意义(P>0.05);不良反应方面,观察组患者未见明显不适,而对照组患者有5例出现口腔异味,8例出现轻度失眠,9例出现腹部胀痛和腹泻,观察组明显优于对照组(P<0.05)。结论:草木犀流浸液片治疗慢性鼻窦炎安全有效,无明显不良反应。

Observation of curative effect of melilotus extract tablet in treatment of chronic sinusitis

Objective Clinical observation on the effect of melilotus extract tablet on chronic sinusitis,explore the drugs in the treat-ment of chronic sinusitis curative effect and less side effect. Method 120 patients with chronic sinusitis outpatient for judgment,were ran-domly divided into observation group and control group,60 cases in each group,the observation group with melilotus extract tablet orally 3 tablets each time,three times a day,continuous treatment for 6 weeks;control group with low dose clarithromycin. In 250 mg,once a day, continuous treatment for 6 weeks;observe and record the two groups before and after treatment in patients with visual analogue score（ VAS） and Lund-Mackey sinus CT score,and adverse drug reactions were found. Results The observation group before treatment,visual analogue score averaged（7. 96 ± 1. 85）,Lund-Mackey sinus CT score averaged（7. 16 ± 1. 51）,6 weeks after the treatment,visual analogue score averaged（3. 28 ± 1. 05）,Lund-Mackey sinus CT score averaged（3. 07 ± 1. 15）;the control group before treatment. Visual ana-logue score averaged（8. 04 ± 1. 79）,Lund-Mackey sinus CT score averaged（7. 08 ± 1. 47）,6 weeks after the treatment,visual ana-logue score averaged（ 3. 41 ± 1. 13 ）,Lund-Mackey sinus CT score averaged（ 3. 18 ± 1. 09 ）;the observation group and the control group before and after treatment in group in comparison,but the difference was significant（ P﹤0. 05 ）between the two groups were com-pared,the difference was not obvious（ P﹥0. 05）;adverse reactions,patients in the observation group had no obvious discomfort,while pa-tients in the control group with 5 cases of oral odor,8 cases had mild insomnia,abdominal pain and diarrhea occurred in 9 cases,the obser-vation group was significantly better than the control group（P﹤0. 05）. Conclusion Melilotus extract tablet in treatment of chronic sinusitis is safe and effective,no obvious adverse reaction.