阿拓莫兰对儿童肝损害多项指标及病程影响的临床观察

目的:观察阿拓莫兰(还原型谷胱甘肽)对儿童肝损害多项指标及病程的影响。方法:应用阿拓莫兰治疗儿童肝损害89例,对照组83例。观察其对肝损害多项指标及病程的影响。结果:疗程结束后两组患者的谷丙转氨酶(ALT)、谷草转氨酶(AST)、谷氨酰转肽酶(GGT)、白蛋白(ALB)和胆红素(TBI)均较治疗前有明显改善;治疗后两组患者在乏力的改变方面有显著性差异,在食欲不振、腹胀、肝区叩击痛的改善方面有非常显著性差异;治疗结束后两组患者食欲不振、腹胀、肝区叩击痛及肝压痛的总改善率也有非常显著性差异。结论:阿拓莫兰对儿童肝病症状、体征及肝功能指标改善效果好,疗程短,速度快,同时对伴有高脂血症的患者具有降低血脂的作用。值得作为一种常规儿童肝损害药物在临床中应用。

A clinical observation on the extension of Moran children with liver damage indexes and the course of

Objective To observe the study of reduced glutathione（ GSH）effect on the indexes and the course of disease in children with liver damage. Method The author applied reduced glutathione for treatment of children with liver injury in 89 cases,83 cases in the control group. Study on the influence on the indexes and the course of liver damage. Results After treatment,two groups of patients with ala-nine aminotransferase（ ALT）,aspartate aminotransferase（ AST ）,glutamyl transpeptidase（ GGT ）,albumin（ ALB ） and total bilirubin （ TBI）significantly improved compared with before treatment. After treatment;two patients in the weak change had significant difference, there was a significant difference in loss of appetite,abdominal distention,liver area percussion pain improvement;total improvement after the treatment in two patients,abdominal distension,loss of appetite liver area percussion pain and liver tenderness had very significant difference. Conclusion Reduced glutathione to function index signs and liver disease symptoms in children with good effect,short course of treatment,fast speed,and has the effect of lowering blood lipids in patients with hyperlipidemia. Worth as a routine clinical application of drugs in children with liver damage.