| 电针任脉联合bFGF对脑缺血大鼠ERK通路的调节作用 |
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| 引用本文： | 刁利红,杨卓欣,罗文舒. 电针任脉联合bFGF对脑缺血大鼠ERK通路的调节作用[J]. 中医药信息, 2006, 23(3): 17-20 |
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| 作者姓名： | 刁利红 杨卓欣 罗文舒 |
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| 作者单位： | 广州中医药大学附属深圳医院,广东,深圳,518033 |
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| 基金项目： | 中国科学院资助项目;广州中医药大学校科研和校改项目;广东省深圳市南山区科技局资助项目 |
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| 摘 要： | 目的:研究电针任脉联合碱性成纤维细胞生长因子(bFGF)对局灶性脑缺血细胞外信号调节激酶(ERK)通路的调节作用。方法:线栓法制作大鼠大脑中动脉栓塞(MCAO)模型。通过Western blot方法研究各组ERK1/2表达和磷酸化的活性特征。结果:MCAO电针联合bFGF治疗后14d,ERK1/2表达在局灶缺血大鼠脑组织中即开始显著升高,ERK1/2磷酸化水平在MCAO后7d开始提高。结论:电针任脉联合bFGF对大鼠局灶性脑缺血的ERK通路起着重要的调节作用,电针任脉联合bFGF治疗对缺血性脑损伤有一定保护作用。
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| 关 键 词： | 脑缺血 电针 碱性成纤维细胞生长因子 细胞外信号调节激酶 大脑中动脉梗死 大鼠 |
| 文章编号： | 1002-2406(2006)02-0017-04 |
| 收稿时间： | 2005-12-28 |
| 修稿时间： | 2005-12-28 |
Effect of electroacupuncture and bFGF on extracellular signal - regulated kinase pathway in focal cerebral inchemia |
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| DIAO Li-hong,YANG Zhuo-xin,LUO Wen-shu. Effect of electroacupuncture and bFGF on extracellular signal - regulated kinase pathway in focal cerebral inchemia[J]. Information on Traditional Chinese Medicine, 2006, 23(3): 17-20 |
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| Authors: | DIAO Li-hong YANG Zhuo-xin LUO Wen-shu |
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| Abstract: | Purpose:To determine the role of electroacupuncture and bFGF on extracellular signal-regulated kinase pathway in focal cerebral ischemia.Methods:Male adultWistar rats underwent right middle cerebral artery occlusion(MCAO)after introducing a nylon suture to the right internal carotid artery.ERK1/2 and there phosphorylation were detected by Western blot analysis.Results:In electroacupuncture and bFGF treated rats,7d after MCAO,the level of ERK1/2 rised compared with the control group rats;and 14d after MCAO,the level of pERK1/2 did.Conclusions:This study demonstrates electroacupuncture and BFGF plays an important role on extracellualar signal-regulated kinase pathway in focal cerebral ischemia.Electroacupuncture and bFGF has protective effects against ischemic brain injury. |
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| Keywords: | Brain Ischemia Electroacupuncture bFGF Extracellular Signal-regulated kinases Middle Cerebral Artery Occlusion Rats |
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