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| 盐酸头孢吡肟在蒙古族和汉族人体内的药动学 | |
| 引用本文： | 夏东亚,郭涛,段威,赵东祥,李强,项勇.盐酸头孢吡肟在蒙古族和汉族人体内的药动学[J].药学服务与研究,2009,9(4):311-314. |
| 作者姓名： | 夏东亚 郭涛 段威 赵东祥 李强 项勇 |
| 作者单位： | 1. 沈阳军区总医院药剂科,沈阳,110016 2. 沈阳军区总医院药剂科,沈阳,110016;沈阳药科大学药学院临床药学系,沈阳,110015 3. 解放军第313医院赤峰临床部药剂科,赤峰,024006 |
| 基金项目： | 全军医学科学技术研究"十一五"计划科技攻关课题基金资助项目 |
| 摘 要： | 目的：研究蒙古族和汉族健康受试者单次静脉滴注盐酸头孢吡肟的药动学。方法：蒙古族和汉族健康受试者各10名,单次静脉滴注盐酸头孢吡肟1.0 g,用HPLC法测定盐酸头孢吡肟血药浓度,用DAS 2.0.1程序拟合估算药动学参数。结果：蒙古族和汉族健康受试者的主要药动学参数分别为：cmax（75.3±13.7）和（68.8±10.4）mg/L;t1/2β（2.1±0.4）和（2.0±0.2）h;Vd（16.4±4.6）和（17.8±3.8）L;AUC0-10.5（148.9±20.7）和（133.7±22.4）mg.h.L-1;AUC0-∞（152.0±23.0）和（136.5±23.2）mg.h.L-1。结论：蒙古族和汉族健康受试者单次静脉滴注盐酸头孢吡肟药动学参数的差异无统计学意义。 |
| 关 键 词： | 盐酸头孢吡肟 药代动力学 蒙古族 汉族 色谱法 高压液相 |
Pharmacokinetics of cefepime hydrochloride in Chinese Mongolian and Han healthy volunteers |
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| XIA Dong-ya,GUO Tao,DUAN Wei,ZHAO Dong-xiang,LI Qiang,XIANG Yong.Pharmacokinetics of cefepime hydrochloride in Chinese Mongolian and Han healthy volunteers[J].Pharmaceutical Care and Research,2009,9(4):311-314. | |
| Authors: | XIA Dong-ya GUO Tao DUAN Wei ZHAO Dong-xiang LI Qiang XIANG Yong |
| Institution: | 1. Department of Pharmacy, General Hospital of Shenyang Military Region of PLA, Shenyang 110016, China; 2. Faculty of Clinical Pharmacy, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110015, China ; 3. Department of Pharmacy, Chifeng Clincal Branch, 313th Hospital of PLA,Chifeng 024006 ,China) |
| Abstract: | Objective：To investigate the pharmacokinetics of cefepime hydrochloride after a single dose intravenous administration in Chinese Mongolian and Han healthy volunteers.Methods：Ten Mongolian volunteers and 10 Han volunteers were given a single dose of 1.0 g cefepime hydrocholoride intravenously.The plasma concentrations of cefepime hydrochloride were determined by HPLC method.The pharmacokinetic parameters were calculated by DAS 2.0.1 software.Results：The main pharmacokinetic parameters in Mongolian and Han volunteers were as follows：cmax（75.3±13.7） and（68.8±10.4） mg/L,t 1/2β（2.1±0.4） and（2.0±0.2） h,Vd（16.4±4.6） and（17.8±3.8） L,AUC0-10.5（148.9±20.7） and（133.7±22.4） mg·h·L-1,AUC0-∞（152.0±23.0） and（136.5±23.2） mg·h·L-1,respectively.Conclusion：There is no significant difference in the pharmacokinetics of cefepime hydrochloride between Chinese Mongolian and Han healthy volunteers. |
| Keywords: | cefepime hydrochloride pharmacokinetics Chinese Mongolian Chinese Han chromatography high pressure liquid |
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