| 南刘寄奴中的一个新1,10-裂环愈创木烷型倍半萜(英文) |
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| 引用本文： | 昝珂,陈筱清,屠鹏飞. 南刘寄奴中的一个新1,10-裂环愈创木烷型倍半萜(英文)[J]. 中国天然药物, 2012, 0(5): 358-362 |
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| 作者姓名： | 昝珂 陈筱清 屠鹏飞 |
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| 作者单位： | [1]北京大学药学院天然药物及仿生药物国家重点实验室,北京100191 [2]首都医科大学中医药学院,北京100069 |
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| 基金项目： | 国家自然科学基金（No.30973629）、中国博士后科学基金（No.20110490251）、北京大学天然药物及仿生药物国家重点实验室开放基金（N0.K20120312）、首都中医药护理专项（No.11ZYH08）资助 |
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| 摘 要： | 目的:研究南刘寄奴中化学成分。方法:采用硅胶和 ODS 等柱层析分离手段以及半制备高效液相, 运用 NMR、MS 以及理化性质鉴定化合物的结构。结果:从南刘寄奴中分离得到 8 个化合物, 其结构鉴定为 3β-ethoxytanapartholide (1), ((4S*,5S*)-dihydro-5-[(1R*, 2S*)-2-hydroxy-2-methyl-5-oxo-3-cyclopenten-1-yl]-3-methylene-4-(3-oxobutyl)-2(3H)-furanone) (2), ligucy-peronol (3), cyperusol C (4), santamarin (5), 1α, 2α, 3α, 4α, 10α-pentahydroxyguaia-11(13)-ene-12, 6α-olide (6), balanophonin (7),methyl 3-(2’-hydroxy-4’-methoxyphenyl) propanoate (8)。结论:化合物 1 是新人工产物, 化合物 4 和 8 为首次从蒿属中分离得到, 化合物 2–3, 5–7 为首次从该植物中分离得到。
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| 关 键 词： | 南刘寄奴 蒿属 化学成分 1,10-裂环愈创木烷型倍半萜 |
A new 1, 10-secoguaianolide from the aerial parts of Artemisia anomala |
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| ZAN Ke,CHEN Xiao-Qing,TU Peng-Fei. A new 1, 10-secoguaianolide from the aerial parts of Artemisia anomala[J]. Chinese JOurnal of Natural Medicines, 2012, 0(5): 358-362 |
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| Authors: | ZAN Ke CHEN Xiao-Qing TU Peng-Fei |
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| Affiliation: | 1State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China; 2School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China |
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| Abstract: | AIM： To study chemical constituents of the aerial parts of Artemisia anomala （Asteraceae）. METHODS： The constituents were isolated with silica gel, ODS column chromatography and semi-preparative HPLC, and their structures were elucidated on the basis of physical characteristics and spectral data. RESULTS： Eight compounds were obtained, and their structures were identified as 3,8-ethoxytanapartholide （1）, （4S＊, 5S＊）-dihydro-5-[（1R＊, 2S＊）-2-hydroxy-2-methyl-5-oxo-3-cyclopenten-1-yl]-3-methylene-4-（3-oxobutyl）- 2（3H）-furanone （2）, ligucyperonol （3）, cyperusol C （4）, santamarin （5）, la, 2a, 3a, 4a, 10a -pentahydroxyguala-11（13）-ene-12, 6a-olide （6）, balanophonin （7）, methyl 3-（2＇-hydroxy-4＇-methoxyphenyl） propanoate （8）. CONCLUSION： Compound 1 was a new artifact, 4 and 8 were isolated from the genus Artemisia for the first time, and compounds 2-3, 5-7 were isolated from this plant for the first time. |
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| Keywords: | Artemisia anomala Chemical constituents 1,10-secogualanolides structure elucidation |
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