| 蝙蝠葛中的化学成分(英文) |
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| 引用本文： | 陈建勇,谢郁峰,周天锡,秦国伟.蝙蝠葛中的化学成分(英文)[J].中国天然药物,2012(4):292-294. |
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| 作者姓名： | 陈建勇 谢郁峰 周天锡 秦国伟 |
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| 作者单位： | [1]中国科学院上海生命科学院上海药物研究所,上海201203 [2]广东药学院药科学院,广州510006 |
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| 基金项目： | 国家自然科学基金（No.30470187）资助项目 |
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| 摘 要： | 目的:研究中药蝙蝠葛的化学成分。方法:应用硅胶和凝胶反复柱层析进行分离,分得成分用波谱分析和理化性质对照进行结构鉴定。结果:分离鉴定出11种成分,分别为dauricumine(1),dauricumidine(2),acutuminine(3),physcion(4),blumenolC(5),blumenolA(6),N-transferuloyltyramine(7),vanillin(8),β-sitostenone(9),β-sitosterol(10),和daucosterol(11)。结论:含氯生物碱1和2为首次从天然来源中分得,含氯生物碱3的NMR数据和立体结构为首次报道,化合物4-11均为首次从本植物中分到。
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| 关 键 词： | 蝙蝠葛 含氯生物碱 化学成分 |
Chemical constituents of Menispermum dauricum |
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| CHEN Jian-Yong,XIE Yu-Feng,ZHOU Tian-Xi,QIN Guo-Wei.Chemical constituents of Menispermum dauricum[J].Chinese JOurnal of Natural Medicines,2012(4):292-294. |
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| Authors: | CHEN Jian-Yong XIE Yu-Feng ZHOU Tian-Xi QIN Guo-Wei |
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| Institution: | 1Shanghai Institute of MateriaMedica, Chinese Academy of Sciences, Shanghai 201203, China; 2Guangdong College of Pharmacy, Guangzhou 510006, China) |
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| Abstract: | AIM： To study the chemical constituents of Menispermum dauricum DC. METHODS： Compounds were isolated by repeated chromatography on silica gel and Sephadex LH-20. The structures were identified by spectral analysis and comparison with literature data. RESULTS： Eleven compounds were obtained and identified as dauricumine （1）, dauricumidine （2）, acutuminine （3）, physcion （4）, blumenol C （5）, blumenolA （6）, N-trans feruloyltyramine （7）, vanillin （8）, β-sitostenone （9）, β-sitosterol （10）, and dancosterol （11）. CONCLUSION： All compounds were known, but isolated from the plant for first time. Compounds 1 and 2 were chlorine-containing alkaloids obtained from natural source for the first time. The stereochemistry of 3 was determined for first time. |
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| Keywords: | Menispermum dauricum Chlorine-containing alkaloids Chemical constituents |
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