| 狼毒大戟的化学成分(英文) |
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| 引用本文： | 王晓阳,刘丽萍,康廷国,王红兵.狼毒大戟的化学成分(英文)[J].中国天然药物,2012(4):299-302. |
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| 作者姓名： | 王晓阳 刘丽萍 康廷国 王红兵 |
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| 作者单位： | [1]辽宁中医药大学药学院,大连116600 [2]同济大学生命科学与技术学院,上海200092 [3]同济大学丽水中药研究院,丽水323000 |
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| 基金项目： | 国家自然科学基金（Nos.81001369,31170327）,中央高校基本科研业务费专项资金（No.2000219078）资助项目 |
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| 摘 要： | 目的:研究狼毒大戟根的化学成分。方法:用多种层析方法对化合物进行分离纯化,根据光谱数据和理化性质鉴定结构。结果:分离并鉴定了11个化合物,即(+)-nyasol(1),23(Z)-环阿尔廷-23-烯-3β,25-二醇(2),环阿尔廷-22-烯-3β,25-二醇(3),月腺大戟素A(4),2,4-二羟基-6-甲氧基-3-醛基苯乙酮(5),α-亚麻酸(6),24-亚甲基环木菠萝烷醇(7),环阿尔廷醇(8),β-谷甾醇(9),3,3’-二乙酰基-4,4’-二甲氧基-2,2’,6,6’-四羟基二苯甲烷(10),狼毒乙素(11)。结论:化合物1为该属首次分离,化合物2-6为该种植物首次分离。
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| 关 键 词： | 大戟科 狼毒大戟 化学成分 三萜 乙酰间苯三酚衍生物 |
Chemical constituents of Euphorbia fischeriana |
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| WANG Xiao-Yang,LIU Li-Ping,KANG Ting-Guo,WANG Hong-Bing.Chemical constituents of Euphorbia fischeriana[J].Chinese JOurnal of Natural Medicines,2012(4):299-302. |
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| Authors: | WANG Xiao-Yang LIU Li-Ping KANG Ting-Guo WANG Hong-Bing |
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| Institution: | 1School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian 116600, China; 2School of Life Sciences and Technology, Tongji University, Shanghai 200092, China; 3 Tongji Universtty-Ltshui lnstitute of Traditional Chinese Medicine, Lishui 323000, China) |
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| Abstract: | AIM： To investigate the chemical constituents in the roots of Euphorbia fischeriana. METHODS： The chemical constituents were isolated and purified by various chromatographic techniques. Their structures were identified on the basis of spectroscopic analyses and physiochemical properties. RESULTS： Eleven compounds were isolated and elucidated as （＋）-nyasol （1）, 23（Z）-cycloart-23-en-3β, 25-diol （2）, cycloart-22-ene-3β, 25-diol （3）, ebracteolatain A （4）, 2, 4-dihydroxy-6-methoxy-3-formyl-1- acetophenone （5）, α-linolenic acid （6）, 24-methylenecycloartanol （7）, cycloartenol （8）, β-sitosterol （9）, 3, 3＇-diacetyl-4, 4＇-dimethoxy-2, 2＇, 6, 6＇-tetrahydroxy diphenylmethane （10）, 2, 4-dihydroxy-6-methoxy-3-methyl-l-acetophenone （11）. CONCLUSION： Compound 1 was found in the genus Euphorbia for the first time and compounds 2-6 were firstly isolated from Euphorbia fischeriana. |
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| Keywords: | Euphorbiaceae Euphorbiafischeriana Chemical constituents Triterpenoids Acetophenone derivatives |
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