食管鳞癌PCNA和c-erbB-2表达与预后的关系

目的 探讨PCNA和c-erbB-2在食管鳞癌组织中表达的意义及其与预后的关系。方法 应用免疫组化SP法对10例正常食管粘膜组织,15例重度不典型增生的食管粘膜组织和87例食管癌组织中PCNA和c-erbB-2的表达进行检测。结果PCNA和c-erbB-2在食管癌组织中均呈异常高表达,与肿瘤病理分级、分期及预后密切相关,而且两者之间存在着协同表达。结论 PCNA增殖指数高与c-erbB-2异常高表达在食管鳞癌的发生和发展过程中起重要作用。提示PCNA和c-erbB-2可作为判断食管癌预后的标记物。

Expression of PCNA and c-erbB-2 proteins in esophageal cancer and their relationships with prognosis

To investigate the roles of CPNA and c-erbB-2 oncogene in the pathogenesis of esophageal cancer and theirrelationships with prognosis. Methods The immunohistochemical methods were adopted to examine the expression of PCNA and c-erbB-2 in 10 normal esopphageal mucosa,15 cases with severe atypical proliferating epithelium and 87 cases with esophageal cancer. Results The overexpression of PCNA and c-erbB-2 were found in esopyhageal cancer, and their expression were closely related with tumor grades and stages and prognosis respectively. Coexpression of two proteins was found in esophageal cancer. Concision The increasing rates of cell proliferation and the abnormal expression of c-erbB-2 may play roles in the development and progression of esophageal cancer. PCNA and c-erbB-2 may be valuable markers for the evaluation of esophageal cancer prognosis