动脉自旋标记法与体素内不相干运动成像在胶质瘤术前应用

目的：探讨三维动脉自旋标记法（3D-ASL）与体素内不相干运动（IVIM）在脑胶质瘤术前分级中的应用价值。方法：选择45例经病理证实的胶质瘤患者（高级别26例,低级别19例）,均行3D-ASL、IVIM-DWI检查,于脑血流量图测量肿瘤实性部分灌注最明显区及健侧CBF值;按双指数模型拟合求得各量化参数,取快ADC（fastADC）图并测量与3D-ASL相同层面肿瘤实性部分与健侧ADC值。结果：高低级别胶质瘤CBF值患侧/健侧比值分别为3.11±1.45、0.86±0.28,fastADC值比值分别为1.88±0.51、0.96±0.31,高低级别组间差异有统计学意义（P〈0.05）。结论：3D-ASL与IVIM技术均可在术前安全无创地提取胶质瘤灌注信息以判断其级别。

Application of arterial spin labeling and intra-voxel incoherent motion imaging in preoperative glioma

Objective：To investigate the three-dimensional arterial spin labeling（ASL） and intra-voxel incoherent motion（IVIM） value in preoperative grading of cerebral glioma. Materials and Methods： Forty-five patients with glioma proved by pathology（26 cases of high grade glioma and 19 cases of low grade glioma） underwent 3D-ASL and IVIM-DWI examination.Cerebral blood flow（CBF） in the most obvious perfusion area of the solid part of tumor and also in the contralateral normal area were measured using cerebral blood flow map. By fitting double exponential model, got the fast ADC map. On 3D-ASL,the ADC value in the solid part of the tumor and also in the contralateral normal area of the same section were measured.Results： CBF ratios of the lesion and contralateral normal area in high and low grade gliomas were 3.11±1.45 and 0.86±0.28 respectively, the fast ADC value were 1.88±0.51 and 0.96±0.31 respectively. There was significant differences between the two groups（P0.05）. Conclusion： 3D-ASL and IVIM techniques are safe and noninvasive methods to extract information of perfusion in gliomas and thus can be used as methods for determining the grade of gliomas before operation.