基于比率低频振幅fMRI评价青少年网络游戏成瘾者静息态下脑功能活动

目的：采用比率低频振幅（fALFF）评价青少年网络游戏成瘾（IGA）者静息态下脑功能区激活特点.方法：对17例符合IGA诊断标准的青少年（IGA组）及19例在年龄、性别、受教育年限、利手等方面相匹配的青少年健康志愿者（正常对照组）行静息态fMRI扫描,两组间fALFF的差异采用两样本t检验.结果：与正常对照组相比,IGA组静息态下双侧额上回及额中回、右侧额内侧回、右侧扣带回前部及左侧扣带回后部、右侧海马旁回、右侧颞下回、右侧楔前叶脑区fALFF增高,差异有统计学意义（P＜0.05,未校正）.右侧颞上回及颞中回、双侧舌回、双侧枕叶、右侧胼胝体压部及双侧小脑脑区fALFF降低,差异有统计学意义（P＜0.05,未校正）.结论：IGA者静息态下脑功能存在异常,fALFF有助于对IGA者静息状态脑功能变化的理解.

Fractional amplitude of low-frequency fluctuation study of resting-state functional MRI in internet gaming addicts of adolescents

Objective： To evaluate brain activity in resting-state in internet gaming addicts of adolescents with fractional amplitude of low-frequency fluctuation （fALFF）. Methods： Seventeen internet gaming addicts of adolescents and nineteen healthy controls, well matched in age, gender, education and handedness, underwent functional MRI in resting-state, and the difference of fALFF between addicts and controls was analyzed with two-sample t test. Results： Comparing with the controls, bilateral dorsal lateral prefrontal cortex （DLPFC）, right medial part of prefrontal cortex （MPFC）, right anterior part of cingulate gyrus （ACC）, bilateral posterior cingulated cortex （PCC）, left limbic lobes, right hippocampus, and right temporal lobes showed increased activation, and decreased activation was found in right temporal lobes, bilateral occipital lobes, right thalamus, right splenium of corpus callosum and of bilateral cerebellum in the addiction group under resting state condition （P〈0.05, uncor- rected）. Conclusion： The resting-state fMRI study suggests abnormal brain activity of internet gaming addicts of adolescents might exist in resting state, and fALFF might contribute to the understanding of internet gaming addicts of adolescents brain function in resting state.