血流细菌感染患者降钙素原水平与SIRS评分的相关性研究

目的探讨血流细菌感染患者血清中降钙素原（PCT）和患者全身炎症反应综合征（SIRS）评分的相关性。方法选择某院2012年1-12月收治的96例血流细菌感染患者作为实验组,按SIRS评分将患者分为A、B、C 3组；选择同期84 例非细菌感染性疾病住院患者作为对照组，检测各组患者PCT水平，并对PCT水平和SIRS评分进行相关性分析。结果实验组96例血流细菌感染患者，死亡7例（7.29%），其中B组死亡4例，C组死亡3例；对照组无死亡病例。对照组以及实验组中A、B、C组PCT水平分别为（0.28±0.09）ng/mL、（0.63±0.13）ng/mL、（3.68±1.01）ng/mL、（7.45±1.53）ng/mL，各组间PCT水平比较，差异有统计学意义（P＜0.01）；4组间两两比较，差异均有统计学意义（均P＜0.001）。对血流细菌感染组患者PCT水平与SIRS评分进行Spearman相关性分析，相关系数r=0.874（P＜0.001），可认为患者血清中PCT水平与SIRS评分呈正相关关系。结论血流细菌感染患者血清中PCT水平与SIRS评分呈正相关，患者血清PCT水平和SIRS评分可作为血流细菌感染患者病情危重程度和预后评估有意义的两项指标。

Correlation between serum procalcitonin concentration and systemic inflammatory response syndrome score in patients with bacterial bloodstream infection

ObjectiveTo evaluate the correlation between serum procalcitonin concentration and systemic inflammatory response syndrome (SIRS) score in patients with bacterial bloodstream infection.MethodsIn January December, 2012, 96 patients with bacterial bloodstream infection in a hospital were selected as trial group, and these patients were divided into three groups(group A,B and C) according to SIRS score; 84 patients without bacterial infection was as control group, PCT concentration of all patients were detected, and the correlation between PCT concentration and SIRS score was analyzed. ResultsAmong 96 patients with bacterial bloodstream infection,7 （7.29%）died (4 were in group B and 3 in group C); there was no death case in control group. PCT concentration in control group, group A,B and C of trial group were （0.28±0.09）ng/mL,（0.63±0.13）ng/mL,（3.68±1.01）ng/mL, and（7.45±1.53）ng/mL，respectively, the difference between each group was significant（P＜0.01）. Pairwise comparison of four groups showed statistical difference (P＜0.001）.Spearman correlation analysis on PCT concentration and SIRS score was conducted, correlation coefficient r=0.874（P＜0.001）suggested positive correlation between serum PCT concentration and SIRS score.ConclusionPCT concentration in patients with bacterial bloodstream infection and SIRS score is positively correlated, PCT concentration and SIRS score can be used as two markers for assessing the extent and prognosis of bacterial bloodstream infection.