某职业病防治医院抗菌药物临床应用专项整治活动效果调查

目的调查某职业病防治医院在抗菌药物临床应用专项整治活动前后抗菌药物使用情况。方法对该职业病防治医院2010年1月-2012年9月门诊及住院患者的抗菌药物使用情况进行统计；2011年5月起，实施抗菌药物临床应用专项整治活动，比较活动实施前后的数据。结果干预后（2011年5月-2012年9月）与干预前（2010年1月-2011年4月）相比，住院患者抗菌药物使用率（29.98% vs 39.45%）和使用强度(AUD 34.60 vs 49.56)显著下降，并且单一用药率(73.04% vs 55.58%)显著上升，抗菌药物使用者标本送检率（74.29% vs 49.87%）显著提高，门诊处方抗菌药物使用率(19.87% vs 43.09%)显著降低（P＜0.005或P＜0.05）。结论通过2011年抗菌药物临床应用专项整治活动，显著改善了抗菌药物临床应用的合理性。

Special rectification activities on clinical application of antimicrobial agents in an occupational diseases prevention and treatment hospital

ObjectiveTo investigate the application of antimicrobial agents before and after the enforcement of special rectification activities in an occupational diseases prevention and treatment hospital. MethodsAntimicrobial application in inpatients and outpatients from January 2010 to September 2012 were analyzed statistically; From May 2011, the special rectification activities on antimicrobial application were carried out, the data before and after intervention was compared.ResultsCompared with pre intervention (between January 2010 and April 2011), data of antimicrobial application after intervention(between May 2011 and September 2012) were as follows: antimicrobial usage rate and antimicrobial use density in inpatients decreased significantly(29.98% vs 39.45%; 34.60 vs 49.56, respectively), single agent application rate and specimen detection rate in patients receiving antimicrobial agents increased significantly(73.02% vs 55.58%;74.29% vs 49.87%,respectively）, the usage rate of antimicrobial agents in outpatients decreased significantly (19.87% vs 43.09%)(P＜0.005 or P＜0.05）.ConclusionThe special rectification activities in 2011 greatly improved the rationality of clinical application of antimicrobial agents.