乳腺浸润性小叶癌弹性成像与临床病理、免疫组化特征相关性分析

目的：利用实时剪切波弹性成像（SWE）技术探讨乳腺浸润性小叶癌硬度与其临床病理及免疫组化特征的相关性.方法：选择经手术病理证实的乳腺浸润性小叶癌患者52例,利用SWE技术术前对乳腺行超声检查,获得包块弹性平均值;术后获得其临床病理及免疫组化特征,并分析其与平均值的相关性.结果：单因素分析结果显示：肿瘤大小、腋窝淋巴结转移、临床分期、组织分级、C-erbB-2、ER与乳腺浸润性小叶癌弹性平均值具有相关性.多因素分析结果显示：肿瘤大小、临床分期、组织分级与乳腺浸润性小叶癌弹性平均值具有独立相关性.结论：乳腺浸润性小叶癌硬度与临床病理特点具有显著相关性,乳腺癌的生物学特性影响其硬度的改变.

Correlation of shear-wave elastography with clinicopathological and immunohistochemical features in breast invasive lobular carcinoma

Objective：To compare the mean elasticity value,as measured by shear-wave elastography （SWE）,with clinicopathological and immunohistochemical features of invasive lobular breast carcinoma.Methods：SWE was performed in 52 cases of breast invasive lobular carcinoma before operation.Mean elasticity values in kPa were measured for each lesion.The clinicopathological and immunohistochemical features were analyzed and correlated with Emean.Results：The result of one-way analysis variance showed that the tumor size,histological grade,axillar lymph node state,clinical tumor stage and the expression of ER and C-erbB-2 were related to the mean elasticity value of invasive lobular breast carcinoma.The result of multivative regression showed that the tumor size,histological grade and clinical tumor stage were independently correlated with the mean elasticity value.Conclusion：The clinicopathological feature of invasive lobular breast carcinoma is significantly associated with the mean elasticity.Biological characteristics of breast cancer influence the change of elasticity value.