普萘洛尔、酚妥拉明对由去甲肾上腺素诱导的家兔肠系膜微血管运动的影响

应用显微录像静画步进法观察家兔肠系膜局部施加去甲肾上腺素（NA）后，诱寻出微动脉周期性、节律性的血管运动及静脉注入普萘洛尔、酚妥拉明对其产生的影响，以期探讨血管运动产生机制及其与α－，β－肾上腺素受体的关系。结果：在家兔颈动脉平均血压为11．40±0．89kPa的条件下，局部施予NA0．8μg于肠系膜观察域，引起微动脉的血管运动，其频率：0．109±0．006Hz，振幅：5．51±0．42μm。同一视野的微静脉和毛细血管未出现血管运动。血管运动的振幅在同一支微动脉上分布不均，呈节段性。普萘洛尔0．1mg／ml·kg-1、0.5mg／ml·kg-1组的内径、血压、血管运动频率及振幅无明显改变，1．0mg／ml·kg-1组的血压无明显变化，内径减小，血管运动频率增加，振幅减小。静脉注入酚妥拉明0．5mg／ml·kg－1及1．0mg／ml·kg-1，颈动脉血压降低，血管内径增加，血管运动频率减少，振幅降低，血管运动被抑制。结论：上述结果表明生理条件下，局部施加NA可以诱导出家兔肠系膜微动脉血管运动，并且血管运动的发生与NA及α－，β-肾上腺素受体有一定关系。

Effects of Propranolol and Phentolamine on Arteriolar Vasomotion in Rabbit Mesentery Caused by Topical Application of Noradrenalin

TV Frame-to-Frame analyzing method was used to observe the characteristies of arteriolar vasomotion in rabbit mesentery caused by topical application of Noradrenalin (NA) 0. 8μg, as well as the effects of intravenous injection of Propranolol and Phentolamine on vasomotion frequency and amplitude, so as to further disguss the mechanism of vasomotion and probable relationship between α-and β-adrenergic receptor and vasomotion. 20 male albino rabbits weighting 2. 0~2. 5 kg were used for the experiment. They were anesthetized with 25% Urethan(0. 75 g/kg) and α-chloralose(30 mg/kg). Topical application of NA 0. 8 μg was conducted to the observation field, vasomotion occured with frequency 0. 109± 0. 006 Hz, amplitude 5. 51 ± 0. 42 μm, amplitude was not uniform on the same arteriole. Propranolol at the dosage of 1. 0 mg/ml· kg-1 significantly decreased the diameter and strengthened vasomotion, both 0. 1 and 0. 5mg/ml·kg-1 groups bed no effects on MABP, mean arteriolar diameter and vasomotion. Phentolamine at the dosage of 0. 5 and 1. 0 mg/ml· kg-1 dosedependently dilated the diameter, decreased the MABP as well as vasomotion. Results above indicate that the mechanism underlying vasomotion is related to α－ and β－adrenergjc receptors.