| cyclin D1、p16蛋白在腮腺多形性腺瘤(PA)和癌在多形性腺瘤中(CPA)的表达及意义 |
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| 引用本文： | 伍虹,黄洪章,王建广,潘朝斌,叶剑涛.cyclin D1、p16蛋白在腮腺多形性腺瘤(PA)和癌在多形性腺瘤中(CPA)的表达及意义[J].现代口腔医学杂志,2003,17(2):100-103. |
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| 作者姓名： | 伍虹 黄洪章 王建广 潘朝斌 叶剑涛 |
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| 作者单位： | 510120,广州,中山医科大学孙逸仙纪念医院口腔颌面外科 |
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| 摘 要： | 目的：检测正常腮腺、PA和CPA中cyclin D1和p16的表达情况及其表达间的相关性。方法：免疫组化S－P法检测cyclin D1和p16的表达。结果：cyclin D1在PA和CPA中的表达率为56．8％和78．6％;p16在PA和CPA中的表达率分别为65％和28．6％。在多数病例（34／51）中cyclin D1和p16呈相反表达,关联系数r=-0.372。结论：cyclin D1与p16表达呈负相关,由它们异常所致细胞周期调控“pRb”通路的异常,在腮腺CPA的发生中可能具有一定的作用。
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| 关 键 词： | p16 cyclin D1 腮腺肿瘤 腮腺多形性腺瘤 |
| 修稿时间： | 2001年9月27日 |
The expression and clinical significance of cyclin D1, p16 in PA and CPA |
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| WU Hong,HUANG Hongzhang,WANG Jianguang,et al..The expression and clinical significance of cyclin D1, p16 in PA and CPA[J].Journal of Modern Stomatology,2003,17(2):100-103. |
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| Authors: | WU Hong HUANG Hongzhang WANG Jianguang |
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| Institution: | WU Hong,HUANG Hongzhang,WANG Jianguang,et al.Department of Stomatology,Sun Yetsen Memorial Hospital,Sun Yetsen University of Medical Sciences,Guangzhou 510120 |
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| Abstract: | ObjectiveTo study the protein expressions of cyclin D1 and p16 in normal parotid, PA and CPA;and to analyse the correlation between their protein expressions.MethodsThe immunohistochemistry was used to detect the expressions of cyclin D1 and p16.ResultsThe positive rates of cyclin D1 and p16 were 56.8%,65% in PA; 78.6%, 28.6% in CPA.In most cases,the expressions of cyclin D1 and p16 were reverse, the correlation rate was - 0.372. ConclusionThere is a negative correlation between the expression of cyclin D1 and p16, which may cause the abnormality of "pRb" pathway of parotid, and play a role in the carcinogenesis of CPA in the parotid gland. |
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| Keywords: | cyclin Dp16Parotid neoplasms |
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