结核分枝杆菌肝素结合血凝黏附素与结核病

结核分枝杆菌肝素结合血凝黏附素是一种表面蛋白,有3个功能结构域,其C末端在翻译后进行甲基化修饰,与其免疫特性相关.可结合硫酸化糖,可通过补体C3介导与巨噬细胞的结合,与上皮细胞结合在肺外结核发病中有重要作用.通过对其细胞免疫及体液免疫作用的研究发现,其在诊断中有较好的作用,在免疫预防及免疫治疗中有广阔的应用前景.

Heparin-binding hemagglutinin adhesion of Mycobacterium tuberculosis and tuberculosis

The heparin-binding hemagglutinin adhesion(HBHA) of Mycobacterium tuberculosis (MTB)is a surface-expressed protein,which has three functional domains.It experiences post'translationally modification of lysine,proline and alanine residues at its carboxyl-terminal that is relative with its immune properties.HBHA can bind with sulfated glycoconj ugates such as heparin,and attach to mononuclear phagocytes by binding to human component C3. Its adhesion to epithelial cells is important to extrapulmonary tuberculosis.HBHA plays a provital role in diagnosis of tuberculosis by cellular immune combining humoral immune assay,and is a viable candidate for tuberculosis vaccine and immune therapy.