腹膜间皮细胞在腹膜纤维化中的作用及机制研究进展

腹膜间皮细胞(PMCs)是腹膜组织的结构细胞,在腹膜纤维化(PF)的发生和发展过程中起着重要作用。PMCs损伤和凋亡是引发和促进PF增生的始动因素之一,其损伤后一方面导致腹膜结构发生改变,同时其分泌蛋白酶、炎性细胞因子及其他促纤维化因子,引起腹膜间质细胞的激活和基质重构,从而触发了PF的发生和发展。另外,PMCs在PF过程中的作用与上述因素及其他细胞(尤其是成纤维细胞)之间的相互作用有关。体外研究发现,PMCs在肿瘤坏死因子β1的诱导下可以向间充质细胞转化,但其在PF过程中所起的作用及分子机制尚有待进一步阐明。

Research Progress about Peritoneal Mesothelial Cells in Peritoneal Fibrosis

Peritoneal mesothelial cells(PMCs)consist of the peritoneal tissue,which play an important role in the pahthogenesis of peritoneal fibrosis(PF).The damages and decease of PMCs is one of the factors triggering and promoting the proliferation of PF.The damaged PMCs lead to the changes of the peritoneal structure,which increases the secretion of the proteases,inflammatory cytokines and other fibrogenic cytokines.It causes the activation of the peritoneal stromal cells and the matrix remodeling,triggering the occurrence of PF.In addition,PMCs play an important role in the above-mentioned factors and other cells,especially with fibroblasts in the pathogenesis of PF.In vitro studies show that PMCs may be transdifferentiated into mesenchymal cells induced by TGF-β1although the mechanisms of PF remain to be further clarified.