486例生殖异常患者的外周血染色体分析研究

目的探讨自然流产和不孕不育与染色体异常的关系。方法采集486例生殖异常患者外周静脉血,常规外周血淋巴细胞培养方法制备染色体标本,G显带技术进行细胞遗传学分析。结果486例生殖异常患者共检出异常核型41例,总检出率8.4%。其中,自然流产患者中检出异常20例,检出率为6.9%(20/288);不孕不育患者中检出异常21例,检出率为10.6%(21/198)。结论染色体异常是导致自然流产及不孕不育的重要原因之一,对生殖异常患者进行染色体检查可为临床诊断和优生优育提供依据。

486 samples analysis of peripheral blood chromosome from reproduction abnormality patients

Objective To investigate the relationship between sterility,spontaneous abortion and abnormal chromosome karyotypes,and that would be help for clinical diagnosis for hereditary disease.Methods To collect peripheral blood samples from 486 reproduction abnormality patients.Chromosome specimens were made using routine culture of peripheral blood lymphocytes.The G-band technique was used in the cytogenetical analysis.Results Forty-one of 486 cases of patients(8.4%) were abnormal chromosome karyotypes.Among the 41 cases involving abnormal karyotypes,there were 20 spontaneous abortion(6.9%),10 sterility(10.6%).Conclusion Chromosome abnormalities are the important factors resulting in female/male infertilities.Chromosome investigation should be tried to do for reproduction abnormality patients.