c-fos、bcl-2基因表达与肠型、弥漫型胃癌的关系

目的：探讨c-fos、bcl-2基因蛋白表达与肠型、弥漫型胃癌的发生的关系，为胃癌分型、早期诊断提供分子病理学依据。方法：用免疫组织化学方法，检测54例胃癌切除标本c-fos、bcl-2基因蛋白的表达，所有结果均用EXCEL录入计算机、SAS统计软件包分析。结果；在肠型胃癌中c-fos、bcl-2基因蛋白表达高于弥漫型胃癌（P＜0.01）；c-fos、bcl-2基因表达淋巴结转移组高于非转移组（c-fos为63.64%、54.55%；bcl-2为50.00%，27.27％），但无统计学意义；c-fos、bcl-2在癌旁组织、异型增生组织和高分化腺癌中呈强阳性表达。结论：c-fos、bcl-2在肠型和弥漫型胃癌中的不同表达表明两型胃癌的发生机制有所不同，可为胃癌分型提供分子病理学依据；c-fos、bcl-2基因蛋白表达变化发生在肿瘤细胞形态变化之前，可作为胃癌早期诊断的分子病理学指标。

Correlation between the expression of gene protein of c-fos, bcl-2 and gastric cancer

Purpose:To investigate the correlation between the expression of gene protein of c-fos,bcl-2 and gastric cancer and to provide the evidence of molecular pathology for grouping and early diagnosis.Methods:The expressions of gene-protein of c-fos,bcl-2 of the resected specimen of 54 patients with gastric carcinoma were detected by immunohistochemical method of S-P.All of the data were input into computer by system of Excel and SAS for statistical analysis.Results:The expressions of gene protein of c-fos,bcl-2 in intestinal type of gastric carcinoma were significantly higher than those in diffuse type (P=0.012, 0.0001, respectively).The expressions of gene protein of c-fos ,bcl-2 in the group of lymphaden metastasis were higher than that in the group of no lymphaden metastasis (c-fos 63.64%,54.55%;bcl-2 50.00%,27.27%), but no statistical significance.The expressions of c-fos , bcl-2 in atypical hyperplasia tissue nearby carcinoma and high differentiated carcinoma were stronger.Conclusions:The expressions of gene protein of c-fos,bcl-2 in intestinal type of gastric carcinoma were significantly higher than those in diffuse type.It showed that the pathogenesis of gastric carcinoma have difference between the intestinal type and diffuse type and it maybe provide proofs for gastric carcinoma grouping.The expression of c-fos,bcl-2 can be used as the molecular pathological symbols for early diagnosis.