| Srcasm负调控Src家族酪氨酸激酶Fyn在人食管鳞状细胞癌TE1细胞株中的表达 |
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| 引用本文： | 齐宇,李鑫,崔广晖,胡伟,赵松.Srcasm负调控Src家族酪氨酸激酶Fyn在人食管鳞状细胞癌TE1细胞株中的表达[J].中华实验外科杂志,2010,27(3). |
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| 作者姓名： | 齐宇 李鑫 崔广晖 胡伟 赵松 |
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| 作者单位： | 1. 郑州大学第一附属医院胸外科,450052
2. 郑州大学第一附属医院肿瘤科,450052 |
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| 摘 要： | 目的 观察人食管鳞状细胞癌TE1细胞株中Srcasm对Src家族酪氨酸激酶Fyn表达的影响.方法 分别转染0、0.25、0.5、1.0、2.0 μg人Srcasm质粒DNA入TE1细胞株中观察其对Fyn表达的影响.结果 转染Srcasm质粒DNA可以降低人食管鳞状细胞癌TE1细胞中Fyn的表达,且呈剂量依赖性.结论 人食管鳞状细胞癌中Srcasm可能是Src家族酪氨酸激酶Fyn的负调控因子,在食管鳞状细胞癌的发生发展过程中起重要作用.
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| 关 键 词： | 食管肿瘤 酪氨酸激酶 |
Srcasm down-regulates src family tyrosine kinases fyn expression in human esophageal squamohus cell carcinoma TE1 cell line |
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| QI Yu,LI Xin,CUI Guang-hui,HU Wei,ZHAO Song.Srcasm down-regulates src family tyrosine kinases fyn expression in human esophageal squamohus cell carcinoma TE1 cell line[J].Chinese Journal of Experimental Surgery,2010,27(3). |
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| Authors: | QI Yu LI Xin CUI Guang-hui HU Wei ZHAO Song |
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| Abstract: | Objective To determine whether Fyn expression was altered in human esophageal squamous cell carcinoma (ESCC) TE1 cell line by TomL1. Methods We transfected 0, 0. 25, 0. 5,1.0, and 2.0 μg Srcasm plasmid DNA into TE1 cells and examined Fyn/Srcasm expression by Western blotting. Results Srcasm decreased the Fyn protein expression in TE1 cells in a dose-dependent manner.Conclusion Srcasm may act as a negative regulator of Fyn in human ESCC, and play an important role in human ESCC progress. |
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| Keywords: | Srcasm |
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