| 嵌段共聚物胶束形态的影响因素 |
| |
| 引用本文： | 徐敏,陈鸿铭,邹豪,高静. 嵌段共聚物胶束形态的影响因素[J]. 第二军医大学学报, 2017, 38(3): 360-365. DOI: 10.16781/j.0258-879x.2017.03.0360 |
| |
| 作者姓名： | 徐敏 陈鸿铭 邹豪 高静 |
| |
| 作者单位： | 1. 第二军医大学药学院药剂学教研室,上海,200433;2. 第二军医大学药学院药剂学教研室,上海200433;解放军69337部队卫生队,塔城834600;3. 第二军医大学药学院药剂学教研室,上海200433;军事医学科学院毒物药物研究所药剂教研室,北京100850 |
| |
| 摘 要： | 嵌段共聚物胶束作为一种有效的药物递送系统受到广泛关注,其具备增加疏水性药物溶解度、延长药物体内循环时间、提高药物稳定性、增强药物治疗效果等优点.胶束的形态可引起其载药和体内分布、药动学行为等性质的重大变化.本文通过对国内外文献的研读,重点探讨了影响嵌段聚合物胶束形态的重要因素(聚合物、制备因素、药物及其他),为今后该类型给药系统的设计提供参考.
|
| 关 键 词： | 嵌段共聚物 胶束 形态 药物载体 |
| 收稿时间： | 2016-09-12 |
| 修稿时间： | 2016-12-28 |
Factors affecting the morphology of block copolymer micelles |
| |
| XU Min,CHEN Hong-ming,ZOU Hao and GAO Jing. Factors affecting the morphology of block copolymer micelles[J]. Former Academic Journal of Second Military Medical University, 2017, 38(3): 360-365. DOI: 10.16781/j.0258-879x.2017.03.0360 |
| |
| Authors: | XU Min CHEN Hong-ming ZOU Hao GAO Jing |
| |
| Affiliation: | Department of Pharmaceutical Science,School of Pharmacy Second Military Medical University Shanghai,Department of Pharmaceutical Science,School of Pharmacy Second Military Medical University Shanghai,Department of Pharmaceutical Science, College of Pharmacy Second Military Medical University |
| |
| Abstract: | Block copolymer micelles have attracted broad attention as an effective drug delivery system. It has many remarkable merits, such as increasing solubility of hydrophobic drug, prolonging drug circulation time in vivo, improving drug stability and enhancing the therapeutic effect of anticancer agents. Micelle morphologyplays an important role in its drug loading,in vivo behavior and pharmacokinetics. Here we provide a review of the critical factors affected the morphology of block copolymer micelles for future reference. |
| |
| Keywords: | block copolymer micelle morphology |
| 本文献已被 万方数据 等数据库收录！ |
| 点击此处可从《第二军医大学学报》浏览原始摘要信息 |
|
点击此处可从《第二军医大学学报》下载全文 |
|
