| 慢性荨麻疹患者血清金黄色葡萄球菌超抗原特异性IgE检测及其意义 |
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| 引用本文： | 张磊,张理涛. 慢性荨麻疹患者血清金黄色葡萄球菌超抗原特异性IgE检测及其意义[J]. 中国中西医结合皮肤性病学杂志, 2016, 0(4): 201-204. DOI: 10.3969/j.issn.1672-0709.2016.04.002 |
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| 作者姓名： | 张磊 张理涛 |
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| 作者单位： | 1. 天津医科大学,天津,300070;2. 天津市中医药研究院附属医院,天津,300120 |
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| 摘 要： | 目的检测慢性荨麻疹(CU)患者血清金黄色葡萄球菌(简称金葡菌)超抗原肠毒素A(SEA)、肠毒素B(SEB)和中毒性休克综合征毒素(TssT-1)的特异性IgE(sIgE),分析该超抗原sIgE与慢性荨麻疹相关性,探讨其发病机制。方法采用酶联免疫吸附试验(Enzyme-linked immunosorbent assay,ELISA)检测63例慢性荨麻疹患者和60例正常对照组血清金葡菌超抗原SEA、SEB和TssT-1的sIgE水平,分别进行金葡菌超抗原(SEA、SEB、TssT-1和SEA/SEB/TssT-1)sIgE比较,并将其浓度与病情程度评分(UAS)进行相关性分析。结果 CU患者血清中金葡菌超抗原(SEB、TssT-1和SEA/SEB/TssT-1)sIgE水平均高于正常对照组,差异有统计学意义(P0.05);金葡菌超抗原(SEA、SEB和SEA/SEB/TssT-1)sIgE水平分别与CU病情轻中重度和荨麻疹活动评分(Urticaria activity score,UAS)呈正相关(P0.05)。结论慢性荨麻疹患者血清中金葡菌肠毒素A、肠毒素B和TssT-1 sIgE水平升高,可能与其慢性病程及严重程度有关。
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| 关 键 词： | 慢性荨麻疹 金葡菌超抗原 超抗原肠毒素A 肠毒素B 中毒性休克综合征毒素-1 特异性IgE |
Detection and Significance of Serum Staphylococcal Superantigens Specific IgE in Chronic Urticaria Patients |
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| Zhang Lei;Zhang Litao. Detection and Significance of Serum Staphylococcal Superantigens Specific IgE in Chronic Urticaria Patients[J]. Chinese J of Dermatovenerology Integr Tradit and West Med, 2016, 0(4): 201-204. DOI: 10.3969/j.issn.1672-0709.2016.04.002 |
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| Authors: | Zhang Lei Zhang Litao |
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| Affiliation: | Zhang Lei;Zhang Litao;Tianjin Medical University;Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital; |
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| Abstract: | |
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| Keywords: | Chronic urticaria Staphylococcal superantigens Staphylococcal enterotoxin A Staphylococcal enterotoxin B Human toxic shock syndrome toxin-1 Special Immunoglobulin E |
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