Ghrelin、肥胖和阻塞性睡眠呼吸暂停低通气综合征

阻塞性睡眠呼吸暂停低通气综合征（obstructive sleep apnea—hypopnea syndrome。OSAHS）是一种由于睡眠期间反复发生上气道塌陷，导致睡眠时打鼾并伴有呼吸暂停和呼吸表浅，夜间反复发生低氧血症、高碳酸血症和睡眠结构紊乱的疾病，可引起白天嗜睡，易引起高血压、糖尿病、心血管疾病。肥胖是OSAHS最显著的易患因素之一。Ghrelin是一种生长激素促分泌素受体（growth hormone secretagogue receptor，GHSR）的内源性配体，它具有多种生物学功能，如刺激生长激素释放，能增加食欲，调节能量平衡，促进胃酸分泌和胃蠕动。研究发现，ghrelin、肥胖、OSAHS之间存在着密切的关系，本文就三者之间的研究进展作一综述。

Relationship between ghrelin, obesity and obstructive sleep apnea hypopnea syndrome

Obstructive sleep apnea hypopnea syndrome(OSAHS is a disabling condition characterized by excessive daytime sleepiness,disruptive snoring,repeated episodes of upper airway obstruction during sleep,and nocturnal hypoxemia.OSAHS is strongly associated with hypertension,diabetes,cardiovascular disease.Obesity is a major risk factor for OSAHS.Ghrelin is secreted mainly by stomach,and is the only nature ligand that has been found by now for growth hormone secretagogue receptor.The receptor of the ghrelin distributes on many tissues,such as brain,heart,lung,pancreas,bowels,fatty tissue and the kidneys.Ghrelin can stimulate the release of growth hormone,regulate appetite,maintain the energy equilibrium etc.People have found that there is relationship between the ghrelin,obesity and OSAHS.This text explains the relationship between them.