Heparanase expression in nasopharyngeal carcinoma inversely correlates with patient survival |
| |
Authors: | Bar-Sela G Kaplan-Cohen V Ilan N Vlodavsky I Ben-Izhak O |
| |
Institution: | Department of Oncology, Rambam Medical Centre, Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa. |
| |
Abstract: | AIMS: To determine the expression and prognostic significance of heparanase in nasopharyngeal carcinoma (NPC). METHODS: Immunohistochemistry was performed on formalin-fixed paraffin-embedded sections of 46 patients with NPC. Clinical and immunohistochemical data were correlated with gender, age, histological type, Epstein-Barr virus (EBV) status, stage and survival. RESULTS: Heparanase immunoreactivity was found in 35% (16/46) of specimens. The cumulative survival of patients diagnosed as heparanase negative (n = 30) at 10 years was 70%. In contrast, the cumulative survival of patients diagnosed as heparanase positive (n = 16) at 10 years was 25%, differences that are highly statistically significant (P = 0.03). No significant correlations were found between heparanase immunoreactivity and gender, age, EBV status, tumour histology or tumour stage. CONCLUSION: Heparanase expression is inversely correlated with survival of NPC patients, clearly indicating that heparanase is a reliable prognostic factor for this malignancy, and further supports the notion that heparanase is a valid target for the development of anti-cancer drugs. |
| |
Keywords: | heparanase nasopharyngeal carcinoma survival tumour |
本文献已被 PubMed 等数据库收录! |
|