Fatty acid alterations in liver peroxisomes from n-3-deficient mice |
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Authors: | Bourre Jean-Marie Dumont Odile Clément Michel |
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Affiliation: | INSERM U705, CNRS UMR 7157, Universités Paris 7 et 5, H?pital Fernand Widal, Paris, France. jean-marie.bourre@fwidal.inserm.fr |
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Abstract: | A diet deficient in n-3 fatty acids dramatically reduces docosahexaenoic acid (4.8-fold) and 20:5n-3 content in murine total peroxisomal phospholipids, and conversely increases 22:5n-6 (17.1-fold) and also, to a lesser extent, 20:4n-6. This was also found in purified phosphatidylethanolamine and phosphatidylcholine. After changing the non-deficient diet (containing alpha-linolenic acid, ALA) to a deficient one (deficient in ALA), it took a very long time for docosahexaenoic acid concentration in peroxisomes to decline (>5 months). In contrast, after changing the deficient to a non-deficient diet, time to complete recovery was more rapid (3 weeks). Changes in 20:5n-3, 22:6n-3 and 20:4n-6 were generally stabilized within 2-4 weeks. Dietary n-3 fatty acids control the fatty acid composition of peroxisomal membranes, and thus possibly affect some of their functions. |
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