| 糖尿病对大鼠睾丸ABP和细胞核雄激素受体的影响 |
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| 引用本文： | 李志盛,王忠山,倪劲松,吴家祥. 糖尿病对大鼠睾丸ABP和细胞核雄激素受体的影响[J]. 吉林大学学报(医学版), 1991, 0(3) |
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| 作者姓名： | 李志盛 王忠山 倪劲松 吴家祥 |
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| 作者单位： | 白求恩医科大学分子生物学中心实验室(李志盛)，白求恩医科大学病理生理教研室(王忠山)，白求恩医科大学病理解剖教研室(倪劲松)，白求恩医科大学病理解剖教研室(吴家祥) |
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| 摘 要： | 22只Wistar大鼠,分为空白对照组(C)10只,糖尿病组(D)6只和糖尿病鱼油治疗组(DFO)6只。静脉注射链脲菌素复制糖尿病模型后80天,处死动物,测定血糖,血浆胰岛素浓度及睾丸雄激素结合蛋白(ABP)和细胞核雄激素受体。结果表明:D和DFO组血糖浓度显著高于C组,而胰岛素显著低于C组,D和DFO组间比较无明显差异,ABP和核雄激素受体在三组间比较无显著差异,提示糖尿病对睾丸雄激素结合蛋白和细胞核雄激素受体无影响。
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| 关 键 词： | 雄激素结合蛋白 雄激素受体 糖尿病 睾丸 大鼠 |
INFLUENCE OF DIABETES ON ABP AND NUCLEAR ANDROGEN RECEPTORS OF TESTIS IN RATS |
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| Li Zhisheng,Ni Jinsong,Wang Zhongshan,Wu JiaxiangCentral Laboratory of Molecular Biology, Dept. of Pathology, Dept.of Pathophysiology. INFLUENCE OF DIABETES ON ABP AND NUCLEAR ANDROGEN RECEPTORS OF TESTIS IN RATS[J]. Journal of Jilin University: Med Ed, 1991, 0(3) |
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| Authors: | Li Zhisheng Ni Jinsong Wang Zhongshan Wu JiaxiangCentral Laboratory of Molecular Biology Dept. of Pathology Dept.of Pathophysiology |
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| Abstract: | Twenty-two male Wistar rats were divided into the control (C) , the diabetic (D) and the diabetic plus fish oil treatment (DFO) groups.Glucose and insulin levels in serum, androgen-binding protein (ABP) and nuclear androgen receptor (NAR) in testis were determined in streptozocin-induced diabetic and the control Wistar rats.The results showed that glucose levels in Dand DFO were siginficantly higher than that in C, and insulin levels in D and DFO were markedly lower than that in C.The difference between D ane DFO was insig-nificant.No significant difference in ABP and NAR in the testis was also observed among C, D and DFO.These findings suggest that diabetes exerts no influence on ABP and NAR. |
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| Keywords: | Androgen-binding protein Nuclear androgen receptor Diabetes Testis Rats |
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