| 兔严重烧伤早期脑水肿MR弥散成像的实验研究 |
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| 引用本文： | 张艳伟,胡俊,黎海涛,林云,陈家飞. 兔严重烧伤早期脑水肿MR弥散成像的实验研究[J]. 第三军医大学学报, 2010, 32(24) |
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| 作者姓名： | 张艳伟 胡俊 黎海涛 林云 陈家飞 |
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| 作者单位： | 1. 第三军医大学西南医院放射科,重庆,400038
2. 第三军医大学西南医院神经内科,重庆,400038 |
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| 基金项目： | 创伤、烧伤与复合伤国家重点实验室开放基金(200704)~~ |
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| 摘 要： | 目的探讨兔严重烧伤早期脑水肿发生、发展过程中MR弥散成像改变特征及其诊断价值。方法 35只健康新西兰大白兔随机数字表法分为对照组及烧伤组(烧伤后1、2、3、4、5、6 h),烧伤组兔均制成50%总烧伤面积Ⅲ度烧伤模型。常规行MRI T1WI、T2WI、DWI、DTI颅脑检查,对各烧伤组和对照组的表观弥散系数(ADC)值、各向异性分数(FA)值,指数表观弥散系数(eADC)值进行动态观察,并用干湿质量法检测其脑含水量的变化。结果烧伤后6 h内,T1WI、T2WI像未见明显变化。与对照组相比,烧伤后4~6 h ADC值明显降低(P<0.01),同时eADC值明显增高(P<0.01),而FA值无明显改变。随着观察时间的延长,脑含水量呈逐渐增高趋势,以伤后3~6 h表现最为显著。脑含水量与ADC值(r=-0.898,P<0.01)、eADC值(r=0.871,P<0.01)的变化呈明显相关性,与FA值无明显相关性(r=0.135,P=0.438)。结论 MR弥散成像能够较好的反映严重烧伤后脑含水量的变化,对烧伤早期明确诊断脑水肿具有重要参考价值。
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| 关 键 词： | 烧伤 脑水肿 兔 磁共振成像 弥散加权成像 弥散张量成像 |
MR diffusion imaging of brain edema in rabbits at primary stage of severe burn |
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| Zhang Yanwei,Hu Jun,Li Haitao,Lin Yun,Chen Jiafei. MR diffusion imaging of brain edema in rabbits at primary stage of severe burn[J]. Acta Academiae Medicinae Militaris Tertiae, 2010, 32(24) |
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| Authors: | Zhang Yanwei Hu Jun Li Haitao Lin Yun Chen Jiafei |
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| Affiliation: | Zhang Yanwei1,Hu Jun2,Li Haitao1,Lin Yun1,Chen Jiafei1(1Department of Radiology,2Department of Neurology,Southwest Hospital,Third Military Medical University,Chongqing,400038,China) |
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| Abstract: | Objective To investigate the features of MR diffusion imaging for a rabbit model of severe burn with brain edema at primary stage and its diagnostic value.Methods Thirty-five healthy New Zealand white rabbits were equally randomized into 7 groups,control group and burn groups(post-burn at 1,2,3,4,5 and 6 h respectively).Severe burn injury was inflicted by 50% total burn surface model with stage III burn.Routine MRI T1WI,T2WI,DWI and DTI with cerebral dynamic observation of apparent diffusion coefficient(ADC... |
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| Keywords: | burn brain edema rabbit magnetic resonance imaging diffusion weighted imaging diffusion tensor imaging |
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