| 神经营养素受体p75NTR介导凋亡的机制及其在眼科的研究 |
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| 引用本文： | 代应辉,李寿玲,陈逖.神经营养素受体p75NTR介导凋亡的机制及其在眼科的研究[J].眼科新进展,2003,23(4):299-301. |
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| 作者姓名： | 代应辉 李寿玲 陈逖 |
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| 作者单位： | 233003,安徽省蚌埠市,蚌埠医学院附属医院眼科 |
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| 摘 要： | p75NTR是一个跨膜糖蛋白，是属于TNF受体超家族成员。NGF、BDNF、NT—3、NT—4／5都可以与p75NTR结合。表达可诱导神经细胞凋亡，可能的途径是激活鞘磷脂通路和转录因子NF-κB。另外还有一些功能相关蛋白参与p75NTR信号传递。p75NTR与某些视网膜神经细胞凋亡关系密切，相关研究已逐渐成为热点。
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| 关 键 词： | 视网膜 p75NTR 凋亡 受体 |
| 文章编号： | 1003-5141(2003)04-0299-03 |
| 修稿时间： | 2002年10月22 |
Mechanism of apoptosis mediated by neurotrophin receptor p75 NTR and study of it in ophthalmology |
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| DAI Ying-Hui,LI Shou-Ling,CHEN Di From the.Mechanism of apoptosis mediated by neurotrophin receptor p75 NTR and study of it in ophthalmology[J].Recent Advances in Ophthalmology,2003,23(4):299-301. |
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| Authors: | DAI Ying-Hui LI Shou-Ling CHEN Di From the |
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| Institution: | DAI Ying-Hui,LI Shou-Ling,CHEN Di From the Department of Ophthalmology,the Affiliated Hospital of Bengbu Medical college,Hefei 230032,Bengbu Province,China |
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| Abstract: | The p75NTR is a transmembrane glycoprotein and a member of the TNF receptor/Fas/CD40 superfamily of receptor. It can bind with the neurotrophins NGF,BDNF, NT-3 and NT-4/5. The p75NTR can influence a variety of functions and mediate apoptotic death. The mechanisms of it signaling remain to be fully understood, possible pathway is to activate JNK and NF-kB . More recently, yeast-two-hybrid and immunoprecipitation techniques have identified several other proteins that appear to interact directly with p75NTR. The p75NTR ran mediate some retina cell to death. Relative study is the focus of considerable attention at present. |
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| Keywords: | retina p75NTR apoptosis receptor |
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