Complex translocations derived stepwise from standard t(15;17) in a patient with variant acute promyelocytic leukemia |
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Authors: | Miyazaki Kaori Kikukawa Masayuki Kiuchi Akihiro Shin Kouichi Iwamoto Toshihiko Ohyashiki Kazuma |
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Affiliation: | Department of Geriatric Medicine, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan. |
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Abstract: | We report the case of an elderly man with an acute promyelocytic leukemia variant carrying complex variant translocations. The Q-banded karyotype and spectral karyotyping method revealed a typical t(15;17), and two complex rearrangements caused by stepwise translocation derived from a typical t(15;17). Chromosomes 8 and 14 were related to these rearrangements. The patient received induction chemotherapy using all-trans retinoic acid and achieved complete remission. To our knowledge, a case with complex rearrangements, caused by apparent stepwise translocation, at diagnosis, has not been reported previously. |
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