Hepatitis B virus infection in pregnant mothers and its transmission to infants |
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| Authors: | Shahana Akhter M Q K Talukder Nurjahan Bhuiyan T A Chowdhury M Nazrul Islam Sufia Begum |
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| Institution: | (1) Department of Obstetrics and Gynaecology, IPGM & R, Dhaka;(2) Department of Virology, IPGM & R, Dhaka;(3) Dhaka Medical College Hospital, Dhaka;(4) Department of Pediatrics, IPGM & R, Shahbagh, Dhaka, Bangladesh |
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| Abstract: | Screening for serological markers of hepatitis B virus infection was done on 500 pregnant mothers. HBsAg, AntiHBs and HBeAg
were done. HBsAg was positive in 3.6%, AntiHBs in 17.4% and HBeAg in 0.4% cases. The infants born to the asymptomatic HBsAg
carrier mothers were followed upto 6 months to determine the vertical transmission of HBV infection. Rate of transmission
of infection from HBsAg positive mothers to infants were 16.66% irrespective of HBeAg status, whereas it was nearly 100% in
case of HBeAg positive mothers. All of the HBsAg positive infants developed the antigenemia between 3–6 months of age, supporting
the hypothesis that intrapartum transmission is the major mode of vertical transmission. |
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| Keywords: | Prevalence HBV infection Vertical transmission |
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