绝经期妇女子宫内膜息肉的病因探讨

目的探讨绝经期子宫内膜息肉的发病原因。方法选择20例未用过任何激素类药物治疗的绝经期子宫内膜息肉患者作为实验组,18例绝经后正常子宫内膜者作为对照组。内膜息肉组均行宫腔镜下息肉切除术,经病理学检查证实为良性子宫内膜息肉。2组均检测外周血性激素水平,子宫内膜息肉和子宫内膜样本均应用免疫组织化学方法测定雌、孕激素受体及细胞增殖核抗原Ki-67含量,用LeicaQ图像分析仪进行测定,用光密度值进行比较。结果实验组和对照组外周血性激素水平比较差异无统计学意义;实验组和对照组腺上皮细胞中雌激素受体光密度分别为(0.56±0.07)和(0.43±0.06);孕激素受体OD值分别为(0.51±0.04)和(0.35±0.06);Ki-67OD值分别为(17.1±7.7)和(9.0±5.5)。上述各指标2组间比较,实验组均呈高表达。结论绝经期子宫内膜息肉的病因与甾体类化合物受体及Ki-67有关,与外周血性激素水平无关。

Etiological Investigation of the Endometrial Polyps in Postmenopausal Women

Objective To investigate the causes and possible mechanism and pathogenesis of endometrial polyps(EP) by evaluating the expression of estrogen receptor(ER),progesterone receptor(PR) so as to try to find the theoretical basis for the treatment and prevention of EP.Methods Prospective study was performed 56 patients,who had transcervical resection of polyps(TCRP) were enrolled.EP and pieces of endometrium had been removed in all operations.Routine pathological diagnosis to all specimens and immunohistochemical staining studies for ER,PR expression in EP and endometrium were made.Serum sex hormones were measured for all patients.Serum sex hormone in 56 patients were all in normal level.Results Expression of ER in gland and stroma of the two groups showed no significant difference(P>0.05).Expression of PR in gland and stroma were significantly decreased in EP group(P<0.05).Conclusion The main mechanisms of EP may be local endometrium wasn't sensitive to the periodic changes of steroid.Abnormal expressions of PR in EP were probably associated with EP formation.