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Elevation of total homocysteine levels in patients with Parkinson's disease treated with duodenal levodopa/carbidopa gel |
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| Authors: | Müller Thomas Jugel Constanze Ehret Reinhard Ebersbach Georg Bengel Gunar Muhlack Siegfried Klostermann Fabian |
| Affiliation: | 1. Department of Neurology, St. Joseph Hospital, Berlin-Weissensee, Gartenstr. 1, 13088, Berlin, Germany 2. Department of Neurology, St. Josef Hospital, Ruhr University Bochum, Gudrunstrasse 56, 44791, Bochum, Germany 3. Department of Neurology, Charit??-University Medicine Berlin, Hindenburgdamm 30, 12203, Berlin, Germany 4. Schlo?str 29, 12163, Berlin, Germany 5. Movement Disorders Clinic, Beelitz-Heilst?tten, Paracelsusring 6A, 14547, Beelitz-Heilst?tten, Germany 6. Department of Neurology, Ernst von Bergmann Hospital, Charlottenstra?e 72, 14467, Potsdam, Germany |
| Abstract: | Levodopa/carbidopa (LD/CD) application elevates total plasma homocysteine (thcys). We determined thcys-, LD- and 3-O-methyldopa (3-OMD) concentrations in 28 patients with Parkinson??s disease (PD) on a LD/CD duodenal gel treatment. We found a distinct thcys increase (29.52?±?28.98???mol/l [median?±?SD]) above the 15???mol/l threshold and a significant (R?=?0.7) correlation between LD and 3-OMD. thcys ascent was observed in relation with the onset of atherosclerosis, non-motor symptoms and polyneuropathy in PD patients in the long term. |
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