| 慢性阻塞性肺疾病患者血清及痰液白细胞介素-8、肿瘤坏死因子的检测及临床意义 |
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| 引用本文： | 杨晶,张爱丽. 慢性阻塞性肺疾病患者血清及痰液白细胞介素-8、肿瘤坏死因子的检测及临床意义[J]. 现代中西医结合杂志, 2007, 16(31): 4598-4599 |
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| 作者姓名： | 杨晶 张爱丽 |
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| 作者单位： | 河北省人民医院,河北,石家庄,050051 |
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| 摘 要： | 目的探讨慢性阻塞性肺疾病(COPD)患者白细胞介素-8(IL-8)及肿瘤坏死因子(TNF-α)水平的变化及在发病中的作用。方法采用酶联免疫吸附法(ELISA)测定30例COPD患者急性加重期和缓解期及20例健康成人的血清及痰液中IL-8、TNF-α含量。结果COPD患者急性加重期血清中IL-8、TNF-α含量显著高于缓解期(P<0.05),缓解期血清IL-8含量显著高于对照组(P<0.05),缓解期血清TNF-α含量与对照组比较无显著性差异(P>0.05);COPD患者急性加重期痰液中IL-8、TNF-α含量显著高于缓解期(P<0.05),缓解期显著高于对照组(P<0.05)。结论IL-8与TNF-α共同参与了COPD气道炎症反应的过程。
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| 关 键 词： | 慢性阻塞性肺疾病 白细胞介素-8 肿瘤坏死因子 |
| 文章编号： | 1008-8849（2007）31-4598-02 |
| 收稿时间： | 2007-07-20 |
| 修稿时间： | 2007-07-20 |
Determination of IL - 8 and TNF - α in serum and sputum and its clinical significance in patients with chronic obstructive pulmonary diseases |
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| YANG Jing,ZHANG Ai-li. Determination of IL - 8 and TNF - α in serum and sputum and its clinical significance in patients with chronic obstructive pulmonary diseases[J]. Modern Journal of Integrated Chinese Traditional and Western Medicine, 2007, 16(31): 4598-4599 |
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| Authors: | YANG Jing ZHANG Ai-li |
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| Abstract: | Objective It is to explore the changes of the levels of IL-8 and TNFα and its function in invasion in patients with chronic obstructive pulmonary diseases(COPD).Methods The concentrations of IL-8 and TNF-α in serum and sputum were determined with enzyme linked immunosorbent assay(ELISA) in 30 cases of patients with COPD in acute aggravating stage and paracmasis and in 20 cases of healthy adults.Results The concentrations of IL-8 and TNF-α in serum and sputum in acute aggravating stage were higher than that in paracmasis(P<0.05).The concentrations in serum and sputum in paracmasis in patients with COPD were higher than in control group except TNF-α in serum(P<0.05).Conclusion IL-8 and TNF-α both take a part in the course of inflammatory reaction of air passage of COPD |
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| Keywords: | chronic obstructive pulmonary diseases IL-8 TNF-α |
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