Statistical evaluation of the in vivo micronucleus assay |
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| Authors: | Ludwig A. Hothorn Daniel Gerhard |
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| Affiliation: | (1) Institute of Biostatistics, Leibniz University, Herrenhauser Str. 2, 30419 Hannover, Germany |
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| Abstract: | The statistical evaluation of the in vivo micronucleus assay is focused on multiple contrast tests for comparisons versus the negative control for count data taking the between-animals variability into account. For a possible claim the compound is not genotoxic in the micronucleus assay a proof of safety approach is proposed. For these statistical approaches user-friendly software is free available. |
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| Keywords: | In vivo micronucleus assay Statistics Software |
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