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Serum matrix metalloproteinase levels correlate with brain injury in human immunodeficiency virus infection |
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| Authors: | Ann B. Ragin Ying Wu Renee Ochs Rachel Scheidegger Bruce A. Cohen Justin C. McArthur Leon G. Epstein Katherine Conant |
| Affiliation: | 1. Department of Radiology, Northwestern University, Chicago, Illinois, USA 2. Center for Advanced Imaging, North Shore Hospital, Evanston, Illinois, USA 3. Harvard-MIT Division of Health Sciences and Technology, Cambridge, Massachusetts, USA 4. Department of Neurology, Northwestern University, Chicago, Illinois, USA 5. Department of Neurology, Johns Hopkins University, Baltimore, Maryland, USA 6. Division of Neurology, Children’s Memorial Hospital, Chicago, Illinois, USA |
| Abstract: | Circulating levels of specific matrix metalloproteinases (MMPs; 1 and 7) were evaluated as correlates of brain injury in eight individuals in advanced human immunodeficiency virus (HIV) infection. Neurological status was quantified in vivo with automated segmentation algorithms and with diffusion tensor imaging. Both metalloproteinases correlated with microstructural brain alterations and the degree of atrophy. MMPs may influence neurological outcome through involvement in neuroimmune response, blood-brain barrier permeability, leukocyte migration, and MMP-mediated neurotoxicity. |
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