| CD/5-Fc联合β射线治疗小鼠胃癌的初步研究 |
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| 引用本文： | 顾琴龙 姬舒荣 刘炳亚 陈雪华 朱正纲 林言箴. CD/5-Fc联合β射线治疗小鼠胃癌的初步研究[J]. 上海交通大学学报(医学版), 2004, 24(2): 85-87 |
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| 作者姓名： | 顾琴龙 姬舒荣 刘炳亚 陈雪华 朱正纲 林言箴 |
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| 作者单位： | 顾琴龙（上海第二医科大学瑞金医院普外科,上海消化外科研究所,上海,200025） 姬舒荣（同济大学同济医院普外科） 刘炳亚（上海第二医科大学瑞金医院普外科,上海消化外科研究所,上海,200025） 陈雪华（上海第二医科大学瑞金医院普外科,上海消化外科研究所,上海,200025） 朱正纲（上海第二医科大学瑞金医院普外科,上海消化外科研究所,上海,200025） 林言箴（上海第二医科大学瑞金医院普外科,上海消化外科研究所,上海,200025） |
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| 基金项目： | 国家卫生部科学研究基金资助项目(98-1-312). |
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| 摘 要： | 目的探索放射治疗联合自杀基因CD治疗小鼠胃癌,以加强自杀基因的抗肿瘤疗效.方法分别以自杀基因CD/5-Fc、β射线及二者联合治疗小鼠胃癌模型,比较治疗效果.结果 CD基因联合放射治疗对肿瘤有明显抑制作用,而且能延长荷瘤鼠的生存期,与CD基因或放疗单独应用相比具有明显差异(P＜0.05).结论放疗能增强自杀基因的疗效,二者联合治疗可以作为肿瘤综合治疗的补充方法.
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| 关 键 词： | CD／5-Fc β射线 治疗 小鼠 胃癌 |
| 文章编号： | 0258-5898(2004)02-0085-03 |
| 修稿时间： | 2003-07-09 |
Preliminary study on murine gastric cancer with combination of CD/5-Fc and beta ray |
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| GU Qin-long,JI Shu-rong,LIU Bing-ya,CHEN Xue-hua,ZHU Zheng-gang,LIN Yan-zhen. Preliminary study on murine gastric cancer with combination of CD/5-Fc and beta ray[J]. Journal of Shanghai Jiaotong University:Medical Science, 2004, 24(2): 85-87 |
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| Authors: | GU Qin-long JI Shu-rong LIU Bing-ya CHEN Xue-hua ZHU Zheng-gang LIN Yan-zhen |
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| Abstract: | Objective This study is aimed to combine radiotherapy with CD gene therapy on murine gastric cancer and to enhance suicide gene therapy. Methods CD gene/5-Fe and (3 ray were used separately or in combination on gastric cancer in mice to compare their effects. Results Tumor growths were suppressed obviously and a longer survival period was observed in mice treated with combined therapy compared to the mice treated with CD gene therapy or radiotherapy alone (P <0. 05) . Conclusion The results showed that radiotherapy enhanced the effect of suicide gene therapy. Gene therapy combined with radiotherapy may be a good supplementary method for cancer synthetic treatment. |
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| Keywords: | suicide gene radiotherapy gastric cancer |
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