重症急性胰腺炎经鼻胃管营养支持的Meta-分析

目的 系统性评价经鼻胃管肠内营养支持在重症急性胰腺炎患者中应用的安全性和有效性.方法 检索中国生物医学文献数据库、Cochrane图书馆、Medline数据库和EMBASE数据库,按Cochrane Handbook手册5.0评定文献质量,用RevMan 4.2软件进行Meta-分析.结果 441篇相关文献中,4篇文献被纳入,共157例患者.Meta-分析显示:经鼻胃管与经鼻窄肠管肠内营养的安全性和可耐受性差异无显著性.结论 现有证据表明经鼻胃管肠内营养对于重症急性胰腺炎患者是安全、有效和可耐受的,但同时需要进行更多大样本、高质量的随机对照研究.

Nasogastric enteral nutrition for severe acute pancreatitis:meta-analysis of clinical trials

Objective To assess the safety and effectiveness of nasegastric enteral nutrition (NGEN) in patients with severe acute pancreatitis (SAP).Methods A meta-analysis of all the relevant clinical trials was performed.Clinical trials were identified from the following electronic databases:Medline,EMBASE,the Cochrane Controlled Trials Register,and Chinese Bio-medicine Database.The search was undertaken in October 2008.The literature quality was evaluated with Cochrane Handbook 5.0.The statistical analysis was performed by RevMan 4.2 software.Results Four trials involving 157 patients were included.The combined results showed that no significant differences in the safety and tolerance between nasogastric and conventional routes in patients with SAP.Conclusions Currently available data show early NGEN appears to be effective,safe,and tolerable in patients with SAP.However,more large-scale high-quality trials are required to further elucidate this topic.