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用SP2/0瘤细胞核或DNA免疫同系小鼠诱导抗核抗体的产生
引用本文:沈璐琳,韩晓辉,郑秀娟,吴厚生. 用SP2/0瘤细胞核或DNA免疫同系小鼠诱导抗核抗体的产生[J]. 现代免疫学, 2001, 21(4): 219-220
作者姓名:沈璐琳  韩晓辉  郑秀娟  吴厚生
作者单位:1. 上海市公共卫生学校,
2. 复旦大学医学院免疫学教研室,
基金项目:自然科学基金资助项目(No.39730430)
摘    要:用SP2 / 0瘤细胞核或DNA分别免疫Balb/c小鼠均可获得IgG抗dsDNA、抗组蛋白、抗Sm、抗SS A/SS B等抗核抗体 ,类似于ConA活化的淋巴细胞的DNA免疫 ,而正常Balb/c小鼠的DNA不能诱导出抗核抗体。实验表明肿瘤细胞的DNA类似于活化细胞的DNA具有免疫原性 ,且能表位扩展到其他核成分

关 键 词:瘤细胞  DNA  抗核抗体  表位扩展
文章编号:1001-2478(2001)04-0219-02
修稿时间:2001-01-12

Induction of Anti-nuclear Antibodies by Immunization with Nuclei and DNAs from SP2/0 Tumor Cells
SHEN Lu lin,HAN Xiao hui,ZHENG Xiu juan,WU Hou sheng. Induction of Anti-nuclear Antibodies by Immunization with Nuclei and DNAs from SP2/0 Tumor Cells[J]. Current Immunology, 2001, 21(4): 219-220
Authors:SHEN Lu lin  HAN Xiao hui  ZHENG Xiu juan  WU Hou sheng
Abstract:The anti nuclear antibodies,such as IgG anti dsDNA,anti histone,anti Sm,anti SSA/SSB,anti rRNP antibodies could be induced in Balb/c mice by immunization with the DNA from SP2/0 tumor cells, similar to those obtained by immunization with the DNA from activated lymphocytes stimulation with ConA.There was no any production of anti nuclear antibodies with DNA from normal Balb/c mice.Experiment results indicate that the DNAs from tumor cells,just like the DNA of activated lymphocytes could express the property of immunogenicity and the phenomenon of epitope spreading could be observed in this experimental study.
Keywords:tumor cell  DNA  anti nuclear antibodies  epitope spreading
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