达体朗治疗酒依赖患者焦虑抑郁障碍的有效性和安全性研究

目的探讨达体朗治疗酒依赖患者焦虑抑郁症状的有效性和安全性。方法采用随机、双盲、安慰剂对照的方法把40例符合纳入和排除标准的患者分成达体朗组和安慰剂组,每组各20人。每个患者均口服安慰剂或达体朗日3次,每次1片,疗程均为8周。在入组前、入组2周和8周后分别进行汉密尔顿焦虑评分量表和抑郁评分量表评分。结果2周后两组汉密尔顿焦虑评分比较差异无显著性(P>0.05),汉密尔顿抑郁评分比较差异有显著性(P<0.05);8周后两组汉密尔顿焦虑和抑郁评分比较差异有显著性(P<0.05或P<0.01)。达体朗组8周后显示治疗焦虑有效率20%,治疗抑郁有效率90%。结论达体朗是改善酒依赖患者焦虑抑郁症状的有效而且安全性较高的药物。

Preliminary Study of Tianeptine in Treatment of Alcoholism with Anxiety and Depression:a Randomized,Double-blind,Placebo-Controlled Study

Objective To study the efficacy and safety of tianeptine in treating alcohol dependence patients with anxiety and depression.Methods The study was a randomized,double-blind,placebo-controlled clinical trial.40 patients are randomly distributed to the tianeptine group or placebo group(20 patients,respectively),who received tianeptine or placebo treatment for 8 weeks.According to the Hamilton Depression Scale(HAMD) and Hamilton Anxiety Scale(HAMA),Every patients was evaluated the score at the pretreatment,the 2nd week and the 8th week of the posttreatment.Results The scores of HAMD were significantly different between the two groups at the 2nd week(P<0.05),but at the same time the scores of HAMA were not significantly different between the two groups(P>0.05),.Either the HAMA scores or the HAMD scores were significantly different between the two groups at the 8th week of the study(P<0.05 or P<0.01).The patients in tianeptine groups showed significant improvement of depression or anxiety symptomatology according to the Hamilton Depression(anxiety) Scale score at the eighth week of the study.The clinical anxiety symptomatology total improved rates were 20 % and the depression symptomatology total improved rates were 90 % at the eighth week of the study.Conclusion The results show that tianeptine not only has better efficacy in treatment of patients with anxiety and depression than placebo,but also has persistent curative effect.