慢性上颌窦炎窦粘膜的免疫组化研究

目的：探讨慢性鼻窦炎局部粘膜中免疫活性细胞和分泌免疫成分在防御炎症过程中的作用。方法：采用免疫组化染色法对两型鼻突炎粘膜的９种免疫活性细胞和４种分泌免疫成分进行检测。结果：鼻窦炎Ⅰ型中Ｔ淋巴细胞、Ｔ４细胞亚群、Ｂ细胞、巨噬细胞明显高于正常对照组（Ｐ〈０．０１）；鼻窦炎Ⅱ型中Ｔ淋巴细胞、Ｔ８细胞亚群、Ｂ细胞、肥大细胞、嗜酸性细胞明显高于正常对照组（Ｐ〈０．０１）；两型中的Ｔ４／Ｔ８细胞比值有明显差异

Immunohistochemical study of the sinus mucosa during chronic maxillary sinusitis

OBJECTIVE: To study the protective role of some immunocompetent cells and some humoral immune factors in the local mucosa during chronic sinusitis. METHOD: Using immunohistochemical streptavidinbiotin peroxide complex (SABC) method to investigate the distribution and the numbers about the T-lymphocytes and subsets, B-cells, macrophages, NK cells, mast cells eosinophils, HLA-DR antigen and IgA, IgG, complement C3, lysozyme in the local mucosa of two type chronic sinusitis. RESULT: The numbers of T-lymphocytes, T helper/inducer cells, B-cells and macrophages in the mucosa of chronic sinusitis type 1 was significantly more than these in the healthy control (P < 0.01). The number of T-lymphocytes, T suppressor cells, B cells, mast cells and eosinophils in the type 2 was significantly more than these in the healthy control (P < 0.01). The ratio of the helper cells to T suppressor cells significant different in the two type chronic sinusitis. CONCLUSION: The study showed that the infiltrating of immunocompetent cells was different between the two type chronic sinusitis.