慢传输型便秘结肠肌间神经丛形态学改变及其临床意义

目的：探讨慢传输型便秘（ＳＴＣ）结肠传输缓慢的神经病理学基础。方法：对１４例ＳＴＣ患者的乙状结肠全层组织进行常规ＨＥ染色、肌间神经丛Ｈｏｌｍｅｓ银浸染色以及Ｓ－１００蛋白免疫组化染色等研究。并与１１例非梗阻性直肠癌患者的正常乙状结肠标本作对照。结果：１４例ＳＴＣ患者乙状结肠肌间神经丛嗜银性反应较对照组均有不同程度的降低，神经纤维排列紊乱并有缠结现象。肌间神经丛内Ｓ－１００蛋白的免疫反应性在ＳＴＣ组

MORPHOLOGICAL CHANGES AND SIGNIFICANCE OF COLONIC MYENTERIC PLEXUS IN PATIENTS WITH SLOW TRANSIT CONSTIPATION

To investigate the neuropathologic changes of colonic myenteric plexus in patients with slow tansit constipation (STC) . Methods: Fourteen patients (1 man and 13 women, mean age, 44 years, ranging from 26-68 years) with STC underwent a partial or total colec-tomy. All resected sigmoid colon specimens were investigated with conventional microscope by way of hematoxylin and eosin stains, Holmes's silver stains and immunohistochemical investigation with the antibody against S-100 protein. Eleven normal sigmoid specimens from the patients with nonobstructed rectal adenocarcinoma were also studied as controls. Results: Silver stains of the myenteric plexus showed quantitative reduction in argyrophilic neurons in varying degree in all of the 14 patients in contrast to the controls. S-100 protein demonstrated an increase in proportion of neural tissue in the myenteric plexus in STC group contrasted with the controls ( P< 0. 01). Conclusion: Distinctive abnormalities of colonic myenteric plexus in the patients with STC were demonstrated. It is probably associated with constant abusion of laxatives.