胱抑素C检测对糖尿病肾病的诊断价值

目的检测血清胱抑素C（Cys-C）浓度并与血清尿素氮（BUN）、肌酐（Cr）、尿α1-MG、β2-MG进行比较，从而评价血清胱抑素在糖尿病肾病的早期诊断的价值。方法应用免疫比浊法测定血清CyS-C浓度，并与血清尿素氮、肌酐、尿α1-MG、β2-MG进行比较。结果CyS—C、α1-MG、β2-MG、BUN、Cr检测结果糖尿病性肾病组较单纯糖尿病组与健康对照组明显增高，差异有非常显著性（P〈0．01），糖尿病性肾病组中Cyst-C、α1-MG、β2-MG和BUN、Cr阳性率分别为96．8（59／62），84．2（52／62），86．9（53／62），68．0％（42／62），72．8％（44／62），血清CyS-C浓度与α1-MG、β2-MG、BUN、Cr比较差异有显著性（P〈0．05）。结论Cyst-C在糖尿病肾病（DN）早期诊断上有较高的检出率，具有一定的诊断价值。

The diagnostic value of cystatin C on diabetic nephropathy

Objective To evaluate cystatin C（Cyst-C） in diagnosis of early diabetic nephropathy by comparing the value of serum Cyst-C with serum urea nitrogen,creatinine,urine α1--macroglobulin and β2-microglobulin. Methods The value of serum Cyst-C was determined by immunoturbidimetry, and was compared with that of serum urea nitrogen, creatinine, urine α1- macroglobulin, β2-microglobulin. Results The values of Cyst-C α1--macroglobulin, β2-microglobulin, urea nitrogen and creatinine nephropathy group were obviously higher than those in diabetes without nephropathy and control groups. The positive rate of Cyst-C,α1-macroglobulin,β2-microglobulin,BUN and Cr was 96. 8% （59/62） ,84.2% （52/62） ,86.9% （53/62） ,68.0% （42/62 and 72. 8% （44/62） respectively. The positive rate of Cyst-C was significantly higher than that of α1-macroglobulin, β2-microglobulin,BUN and Cr. Conclusion Cyst-C has a certain value in diagnosis of early diabetic nephropathy.