Clinical validation of a new blood collection tube for the accuracy of total homocysteine measurement by different methods |
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| Authors: | Bissé Emmanuel Epting Thomas Kögel Gabriele Obeid Rima Gempel Klaus Huzly Daniela Fuhrmann Klaus Rolinski Boris Herrmann Wolfgang Wieland Heinrich |
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| Affiliation: | Department of Clinical Chemistry, University Medical Center Freiburg, Hugstetterstrasse 55, D-79106 Freiburg, Germany. bisse@med1.ukl.uni-freiburg.de |
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| Abstract: | OBJECTIVE: To evaluate the clinical use of Homocysteine-Primavette, a new blood collection medium for total homocysteine (tHcy) assay. METHODS: The agreement between baseline tHcy and tHcy in stabilized samples (40 h) was assessed for FPIA, HPLC, GC-MS, LC-MS, and ICL. RESULTS: tHcy concentrations in whole blood were stable for 40 h in Hcy-Primavette tubes. CONCLUSION: Primavette tubes are a good alternative for the accurate tHcy measurement and no readjustment of reference intervals is needed. |
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