海南地区不同人群TTV感染的流行病学研究

「目的」研究海南地区不同人群ＴＴＶ感染情况。「方法」对１６２例城市一般人群、１５３例农村少数民族、１２０例献血员、９６例丙氨酸氨基转移酶异常者、６８例血透析者、９２例非甲～庚型肝炎病人、１０２例甲～庚型肝炎病海南地区以上８种人群中的阳性率依次为１０．５％、８．５％、９．２％、１１．５％、１７．６％、４０．２％、２６．５％、３８．７％，各类人员之间差异非常显著（Ｐ〈０．０１）；ＴＴＶ阳性甲～庚型肝炎

A Epidemiologic Study of TT Virus Infection Among Various Populations in Hainan

Objective] To study TT virus infection among various populations in HaiNan.[Methods] The blood samples were from 8 different individuls groups. TTV DNA in serum sampies was detected by nested-polymerase chain reaction, partial gene of two strains of TTV was cloned and sequenced, and their genetic variation was analyzed.[Result] TTV DNA was detected in the sera from 17 of 162(10.5%) general individuals, 13 of 153(8.5%) countryside minority individuals, 11 of 120 (9.2%) blood donors, 11 of 96 (11.5%) elevated alanine aminotransferase persons, 12 of 68 (17.6%) hemodialysis patients, 37 of 92 (40.2%) patients with non-A to G hepatitis, 27 of 102 (26.5%) patients with A to G hepatitis, 7 of 181 (38.7%) intravenous drug users. There wrer significant different in various population (P<0 01). The sequence Analysis show that there were above 98% nucleotide identity among AB017610 (from Japan), AB011490 (from Japan).[Conclusion] The results of the study suggest that TTV infection is common in various populations in HaiNan. The intravenous drug users and patients with non-A to G hepatitis are the population at high risk for TTV infection.